Fig. 1

Brain MRI showing the response and the progression of the leptomeningeal disease with BRAF inhibitor-based therapy. The arrows indicate the enhancement of the leptomeninges in April 2013. After vemurafenib therapy, the follow-up images revealed initial regression of the leptomeningeal disease. He had progression of the leptomeningeal disease in October 2013 and started whole brain radiation followed by dabrafenib plus trametinib. The follow-up scans showed regressed leptomeningeal disease