Prognostic model for long-term survival of locally advanced non-small-cell lung cancer patients after neoadjuvant radiochemotherapy and resection integrating clinical and histopathologic factors

Table 3 Significant prognostic variables from proportional hazard regression analysis of survival data

	model (1) containing clinical + pathol. covariates		standard model (2) containing clinical covariates alone
variable	Hazard ratio	p-value	Hazard ratio	p-value
pCR	0.41 (0.25–0.67)	p = 0.0003	not included
cN3	1.52 (1.01–2.29)	p = 0.047	1.59 (1.06–2.39)	p = 0.027
gender (female)	0.57 (0.38–0.87)	p = 0.008	0.63 (0.42–0.94)	p = 0.025
CT - tumor response	Backward eliminated	n.s.	0.59 (0.39–0.91)	p = 0.017

Model (1) contains all clinical and pathological covariates, as described under Methods. Backward elimination of non-significant variables was used for reduced model selection. CT-tumor response: partial or complete response after neoadjuvant radiochemotherapy in comparison to the pretreatment computed tomography imaging study.

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