Figure 3
From: ZFP36 stabilizes RIP1 via degradation of XIAP and cIAP2 thereby promoting ripoptosome assembly
ZFP36 controls RIP1 stability in glioma neural stem cells. Human G144 glioma neural stem cells were grown in adhesion in proliferation medium and transduced with a short hairpin lentivirus directed against ZFP36 (shZFP36) or with a scrambled short hairpin sequence (pGIPZ) and sorted based on eGFP-positivity. Western blot analysis suggests that RIP1 stability is reduced in the absence of ZFP36 (shZFP36) when compared to G144 that retain ZFP36 expression (pGIPZ).