Skip to main content

Table 6 Chk1 inhibitors reduced TH-302-mediated HT-29 cell-cycle arrest

From: Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition

TH-302 μM

Hypoxia (N2)

TH-302

TH-302 + 0.1 μM AZD

 

%G0/G1

%S

%G2/M

%G0/G1

%S

%G2/M

0

53

21

25

62

19

19

0.125

36

17

47

45

17

37

0.25

25

15

59

40

15

42

0.5

17

20

62

28

19

49

1

15

30

54

22

19

55

2

14

51

33

24

18

53