From: Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition
TH-302 μM | Hypoxia (N2) | |||||
---|---|---|---|---|---|---|
TH-302 | TH-302 + 0.1 μM AZD | |||||
 | %G0/G1 | %S | %G2/M | %G0/G1 | %S | %G2/M |
0 | 53 | 21 | 25 | 62 | 19 | 19 |
0.125 | 36 | 17 | 47 | 45 | 17 | 37 |
0.25 | 25 | 15 | 59 | 40 | 15 | 42 |
0.5 | 17 | 20 | 62 | 28 | 19 | 49 |
1 | 15 | 30 | 54 | 22 | 19 | 55 |
2 | 14 | 51 | 33 | 24 | 18 | 53 |