From: Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition
Oxygen | TH-302 (μM) | Combination index (CI) | ||
---|---|---|---|---|
TH-302 + 0.1 μM AZD | TH-302 + 0.5 μM LY | TH-302 + 0.4 μM PF | ||
Normoxia (21% O2) | 0.001 | 0.001 | 0.001 | 0.001 |
0.01 | 0.001 | 0.001 | 0.001 | |
0.1 | 0.02 | 0.04 | 0.01 | |
1 | 0.02 | 0.12 | 0.05 | |
10 | 0.24 | 0.18 | 0.17 | |
100 | 0.65 | 0.66 | 0.61 | |
 | 1000 | 0.84 | 0.84 | 0.81 |
Hypoxia (N2) | 0.0001 | 0.001 | 0.001 | 0.001 |
0.001 | 0.001 | 0.001 | 0.001 | |
0.01 | 0.05 | 0.05 | 0.02 | |
0.1 | 0.36 | 0.25 | 0.23 | |
1 | 0.74 | 0.69 | 0.67 | |
10 | 0.86 | 0.86 | 0.84 | |
100 | 0.9 | 0.93 | 0.93 |