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Table 2 Near additivity or strong synergism was observed in combination groups

From: Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition

Oxygen

TH-302 (μM)

Combination index (CI)

TH-302 + 0.1 μM AZD

TH-302 + 0.5 μM LY

TH-302 + 0.4 μM PF

Normoxia (21% O2)

0.001

0.001

0.001

0.001

0.01

0.001

0.001

0.001

0.1

0.02

0.04

0.01

1

0.02

0.12

0.05

10

0.24

0.18

0.17

100

0.65

0.66

0.61

 

1000

0.84

0.84

0.81

Hypoxia (N2)

0.0001

0.001

0.001

0.001

0.001

0.001

0.001

0.001

0.01

0.05

0.05

0.02

0.1

0.36

0.25

0.23

1

0.74

0.69

0.67

10

0.86

0.86

0.84

100

0.9

0.93

0.93