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Table 1 Enhanced IC 50s were observed in combination groups

From: Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition

 

Normoxia (21% O2)

Hypoxia (N2)

HCR

 

IC50(μM)

IC50(μM)

Normoxia/Hypoxia

TH-302

1000

10

100

AZD 7762

0.4

N/A

N/A

LY 2603618

1.7

N/A

N/A

PF 477736

0.8

N/A

N/A

TH-302 and 0.1 μM AZD

39

0.2

195

TH-302 and 0.5 μM LY

46

0.4

115

TH-302 and 0.4 μM PF

57

0.4

140