From: Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition
 | Normoxia (21% O2) | Hypoxia (N2) | HCR |
---|---|---|---|
 | IC50(μM) | IC50(μM) | Normoxia/Hypoxia |
TH-302 | 1000 | 10 | 100 |
AZD 7762 | 0.4 | N/A | N/A |
LY 2603618 | 1.7 | N/A | N/A |
PF 477736 | 0.8 | N/A | N/A |
TH-302 and 0.1 μM AZD | 39 | 0.2 | 195 |
TH-302 and 0.5 μM LY | 46 | 0.4 | 115 |
TH-302 and 0.4 μM PF | 57 | 0.4 | 140 |