Autoantibodies in breast cancer sera are not epiphenomena and may participate in carcinogenesis

BMC Cancer

Table 2 ANAs and anti-cytoplasmic antibodies on HEp-2 cells in BC and non-cancer control sera

IFA pattern [%]*	Convenience control female	Osteoarthritis control female	Benign breast disease	Ductal carcinoma in situ	Invasive carcinoma
Homogeneous	6	7	46	41	29
Speckled	7	11	8	17	38
Anti-nucleolar	2	3	30	27	32
Anti-centromere	0	0	2	5	5
Anti-centrosome	0	0	16	18	12**
Anti-mitochondrial	0	0	10	11	22
Multiple nuclear dots	0	0	3	3	5
Cytoskeletal	0	0	0	3	3
Mixed pattern	2	9	37	45	51
Other	0	1	3	5	4

*Percent of individual patterns do not add up to 100% due to high frequency of mixed patterns.
**Percent likely underestimates prevalence of anti-centrosome antibodies because of the masking effect of the high frequency of cytoplasmic speckles and heavy mitochondrial fluorescence in sera from invasive breast carcinoma.

ISSN: 1471-2407