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Table 2 ANAs and anti-cytoplasmic antibodies on HEp-2 cells in BC and non-cancer control sera

From: Autoantibodies in breast cancer sera are not epiphenomena and may participate in carcinogenesis

IFA pattern [%]* Convenience control female Osteoarthritis control female Benign breast disease Ductal carcinoma in situ Invasive carcinoma
Homogeneous 6 7 46 41 29
Speckled 7 11 8 17 38
Anti-nucleolar 2 3 30 27 32
Anti-centromere 0 0 2 5 5
Anti-centrosome 0 0 16 18 12**
Anti-mitochondrial 0 0 10 11 22
Multiple nuclear dots 0 0 3 3 5
Cytoskeletal 0 0 0 3 3
Mixed pattern 2 9 37 45 51
Other 0 1 3 5 4
  1. *Percent of individual patterns do not add up to 100% due to high frequency of mixed patterns.
  2. **Percent likely underestimates prevalence of anti-centrosome antibodies because of the masking effect of the high frequency of cytoplasmic speckles and heavy mitochondrial fluorescence in sera from invasive breast carcinoma.