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Table 1 Clinico-pathological characteristics of the patient cohort

From: Fractal analysis of nuclear histology integrates tumor and stromal features into a single prognostic factor of the oral cancer microenvironment

  # Of cases (%) nFD lowa nFD higha FEP- value DSS (LRP- value)
Number of events - - 33 1 - -
Gender      0.81 0.457
Male 70 65.42 53 17
Female 37 34.58 29 8
Age 107 NA 61.1b 59.8b 0.68 nd
pT-Stage      0.01 0.01
pT1/pT2 (low) 61 57.01 41 20
pT3/pT4 (high) 44 41.12 40 4
Missing 2 1.87 1 1
pN-status      0.25 0.02
pN0 66 61.68 48 18
pN1/pN2 41 38.32 34 7
Smoking history      0.60 0.27
Never 28 26.168 20 8
Ever 78 72.897 61 17
Missing 1 0.935 1 0
Alcohol history      0.43 0.14
Never 11 10.28 10 1
Ever 57 53.27 43 14
Missing 39 36.45 29 10
Tumor differentiation      0.23 0.18
Well 15 14.02 10 5
Moderate 56 52.34 47 9
Poor 12 11.21 9 3
Missing 24 22.43 16 8
Treatment      0.01 0.03
Surgery 34 31.78 20 14
Surgery + RT 73 68.22 62 11
Ki67       
Low 43 76.19 40 3 0.001 0.002
High 62 23.81 40 22   
LI       
Low 53 50.47 48 5 0.001 0.002
High 52 49.43 32 20   
  1. aCut-point was determined using X-tile.
  2. bMean age.
  3. nFD: nuclear fractal dimension; pT-stage: pathological T-stage; pN status: pathological node status; RT: radiotherapy; FE: Fisher’s exact; LR: logrank, LI: lymphocytic infiltration. Significant P - values are shown in BOLD.