|
Characteristics
|
Univariate analysis
|
Multivariate analysis
|
|---|
| |
No. (%)
|
pvalue
|
Hazard ratio
|
95% CI
|
Pvalue
|
|---|
|
Sex
| |
0.766
| | | |
|
Male
|
341 (80.6)
| | | | |
|
Female
|
82 (19.4)
| | | | |
|
Age (yr)
| |
0.013*
|
1.473
|
1.079 - 2.012
|
0.015*
|
|
≤54
|
146 (34.5)
| | | | |
|
>54
|
277 (65.5)
| | | | |
|
Tumor location
| |
0.485
| | | |
|
Upper
|
36 (8.5)
| | | | |
|
Middle
|
252 (59.6)
| | | | |
|
Lower
|
135 (31.9)
| | | | |
|
Degree of differentiation
| |
0.167
| | | |
|
Poorly or not differentiated
|
159 (37.6)
| | | | |
|
Moderately differentiated
|
251 (59.3)
| | | | |
|
Poorly differentiated
|
13 (3.1)
| | | | |
|
TNM stage (AJCC, 7th)
| |
<0.001*
| | |
<0.001*
|
|
I
|
54 (12.8)
| |
1
|
Reference
| |
|
II
|
168 (39.7)
| |
1.913
|
0.973 – 3.760
|
0.060
|
|
III
|
142 (33.6)
| |
4.231
|
2.178 – 8.220
|
<0.001*
|
|
IV
|
59 (13.9)
| |
3.552
|
1.405 – 8.978
|
0.007*
|
|
Distant metastasis
| |
<0.001*
| | | |
|
No
|
364 (86.1)
| | | | |
|
Yes
|
59 (13.9)
| | | | |
|
Surgery
| |
<0.001*
| | | |
|
No
|
60 (14.2)
| | | | |
|
Yes
|
363 (85.8)
| | | | |
|
Treatment purpose
| |
<0.001*
|
2.113
|
1.099 – 4.061
|
0.025*
|
|
Curative treatment
|
358 (84.6)
| | | | |
|
Palliative treatment
|
65 (15.2)
| | | | |
|
BMI (Kg/m2)
| |
<0.001*
|
0.663
|
0.496 – 0.885
|
0.005*
|
|
≤20.43
|
158 (37.4)
| | | | |
|
>20.43
|
257 (60.8)
| | | | |
|
CRP/Alb
| |
<0.001*
|
1.393
|
1.031 – 1.883
|
0.031*
|
|
≤0.095
|
276 (65.2)
| | | | |
|
>0.095
|
147 (34.8)
| | | | |
|
mGPS
| |
0.003*
| | | |
|
0
|
345 (81.6)
| | | | |
|
1
|
70 (16.5)
| | | | |
|
2
|
8 (1.9)
| | | | |
|
PNI
| |
0.002*
| | | |
|
≤49.05
|
102 (24.1)
| | | | |
|
>49.05
|
321 (75.9)
| | | | |
|
NLR
| |
0.018*
| | | |
|
≤1.835
|
139 (32.9)
| | | | |
|
>1.835
|
284 (67.1)
| | | | |
|
PLR
| |
0.026*
| | | |
|
≤163.8
|
327 (77.3)
| | | | |
|
>163.8
|
96 (22.7)
| | | | |
|
CRP (mg/L)
| |
0.002*
| | | |
|
≤10
|
345 (81.6)
| | | | |
|
>10
|
78 (18.4)
| | | | |
|
WBC (×10^9/L)
| |
0.365
| | | |
|
≤10
|
373 (88.2)
| | | | |
|
>10
|
50 (11.8)
| | | | |
|
Albumin (g/L)
| |
0.041*
| | | |
|
≤35
|
8 (1.9)
| | | | |
|
>35
|
415 (98.1)
| | | | |
- *Statistically significant prognostic factor identified by univariate/multivariate analysis.
- Abbreviation: CI confidence interval, TNM tumor-node-metastasis, AJCC American Joint Committee on Cancer, BMI body mass index, CRP/Alb the C-reactive protein/Albumin ratio, mGPS the modified Glasgow Prognostic Score, PNI the prognostic nutritional index, NLR the neutrophil lymphocyte ratio, PLR the platelet lymphocyte ratio, CRP C-reactive protein, WBC white blood cell.
- The cut-off values for age, BMI, CRP/Alb, PNI, NLR and PLR were determined by the method described in statistic analysis. CRP, WBC and Albumin were categorized according to clinical normal reference range.
