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Table 2 Prognostic factors for overall survival identified by univariate and multivariate analyses

From: A novel inflammation-based prognostic score in esophageal squamous cell carcinoma: the C-reactive protein/albumin ratio

Characteristics

Univariate analysis

Multivariate analysis

 

No. (%)

pvalue

Hazard ratio

95% CI

Pvalue

Sex

 

0.766

   

Male

341 (80.6)

    

Female

82 (19.4)

    

Age (yr)

 

0.013*

1.473

1.079 - 2.012

0.015*

≤54

146 (34.5)

    

>54

277 (65.5)

    

Tumor location

 

0.485

   

Upper

36 (8.5)

    

Middle

252 (59.6)

    

Lower

135 (31.9)

    

Degree of differentiation

 

0.167

   

Poorly or not differentiated

159 (37.6)

    

Moderately differentiated

251 (59.3)

    

Poorly differentiated

13 (3.1)

    

TNM stage (AJCC, 7th)

 

<0.001*

  

<0.001*

I

54 (12.8)

 

1

Reference

 

II

168 (39.7)

 

1.913

0.973 – 3.760

0.060

III

142 (33.6)

 

4.231

2.178 – 8.220

<0.001*

IV

59 (13.9)

 

3.552

1.405 – 8.978

0.007*

Distant metastasis

 

<0.001*

   

No

364 (86.1)

    

Yes

59 (13.9)

    

Surgery

 

<0.001*

   

No

60 (14.2)

    

Yes

363 (85.8)

    

Treatment purpose

 

<0.001*

2.113

1.099 – 4.061

0.025*

Curative treatment

358 (84.6)

    

Palliative treatment

65 (15.2)

    

BMI (Kg/m2)

 

<0.001*

0.663

0.496 – 0.885

0.005*

≤20.43

158 (37.4)

    

>20.43

257 (60.8)

    

CRP/Alb

 

<0.001*

1.393

1.031 – 1.883

0.031*

≤0.095

276 (65.2)

    

>0.095

147 (34.8)

    

mGPS

 

0.003*

   

0

345 (81.6)

    

1

70 (16.5)

    

2

8 (1.9)

    

PNI

 

0.002*

   

≤49.05

102 (24.1)

    

>49.05

321 (75.9)

    

NLR

 

0.018*

   

≤1.835

139 (32.9)

    

>1.835

284 (67.1)

    

PLR

 

0.026*

   

≤163.8

327 (77.3)

    

>163.8

96 (22.7)

    

CRP (mg/L)

 

0.002*

   

≤10

345 (81.6)

    

>10

78 (18.4)

    

WBC (×10^9/L)

 

0.365

   

≤10

373 (88.2)

    

>10

50 (11.8)

    

Albumin (g/L)

 

0.041*

   

≤35

8 (1.9)

    

>35

415 (98.1)

    
  1. *Statistically significant prognostic factor identified by univariate/multivariate analysis.
  2. Abbreviation: CI confidence interval, TNM tumor-node-metastasis, AJCC American Joint Committee on Cancer, BMI body mass index, CRP/Alb the C-reactive protein/Albumin ratio, mGPS the modified Glasgow Prognostic Score, PNI the prognostic nutritional index, NLR the neutrophil lymphocyte ratio, PLR the platelet lymphocyte ratio, CRP C-reactive protein, WBC white blood cell.
  3. The cut-off values for age, BMI, CRP/Alb, PNI, NLR and PLR were determined by the method described in statistic analysis. CRP, WBC and Albumin were categorized according to clinical normal reference range.