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Table 2 Prognostic factors for overall survival identified by univariate and multivariate analyses

From: A novel inflammation-based prognostic score in esophageal squamous cell carcinoma: the C-reactive protein/albumin ratio

Characteristics Univariate analysis Multivariate analysis
  No. (%) pvalue Hazard ratio 95% CI Pvalue
Sex   0.766    
Male 341 (80.6)     
Female 82 (19.4)     
Age (yr)   0.013* 1.473 1.079 - 2.012 0.015*
≤54 146 (34.5)     
>54 277 (65.5)     
Tumor location   0.485    
Upper 36 (8.5)     
Middle 252 (59.6)     
Lower 135 (31.9)     
Degree of differentiation   0.167    
Poorly or not differentiated 159 (37.6)     
Moderately differentiated 251 (59.3)     
Poorly differentiated 13 (3.1)     
TNM stage (AJCC, 7th)   <0.001*    <0.001*
I 54 (12.8)   1 Reference  
II 168 (39.7)   1.913 0.973 – 3.760 0.060
III 142 (33.6)   4.231 2.178 – 8.220 <0.001*
IV 59 (13.9)   3.552 1.405 – 8.978 0.007*
Distant metastasis   <0.001*    
No 364 (86.1)     
Yes 59 (13.9)     
Surgery   <0.001*    
No 60 (14.2)     
Yes 363 (85.8)     
Treatment purpose   <0.001* 2.113 1.099 – 4.061 0.025*
Curative treatment 358 (84.6)     
Palliative treatment 65 (15.2)     
BMI (Kg/m2)   <0.001* 0.663 0.496 – 0.885 0.005*
≤20.43 158 (37.4)     
>20.43 257 (60.8)     
CRP/Alb   <0.001* 1.393 1.031 – 1.883 0.031*
≤0.095 276 (65.2)     
>0.095 147 (34.8)     
mGPS   0.003*    
0 345 (81.6)     
1 70 (16.5)     
2 8 (1.9)     
PNI   0.002*    
≤49.05 102 (24.1)     
>49.05 321 (75.9)     
NLR   0.018*    
≤1.835 139 (32.9)     
>1.835 284 (67.1)     
PLR   0.026*    
≤163.8 327 (77.3)     
>163.8 96 (22.7)     
CRP (mg/L)   0.002*    
≤10 345 (81.6)     
>10 78 (18.4)     
WBC (×10^9/L)   0.365    
≤10 373 (88.2)     
>10 50 (11.8)     
Albumin (g/L)   0.041*    
≤35 8 (1.9)     
>35 415 (98.1)     
  1. *Statistically significant prognostic factor identified by univariate/multivariate analysis.
  2. Abbreviation: CI confidence interval, TNM tumor-node-metastasis, AJCC American Joint Committee on Cancer, BMI body mass index, CRP/Alb the C-reactive protein/Albumin ratio, mGPS the modified Glasgow Prognostic Score, PNI the prognostic nutritional index, NLR the neutrophil lymphocyte ratio, PLR the platelet lymphocyte ratio, CRP C-reactive protein, WBC white blood cell.
  3. The cut-off values for age, BMI, CRP/Alb, PNI, NLR and PLR were determined by the method described in statistic analysis. CRP, WBC and Albumin were categorized according to clinical normal reference range.