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Figure 4 | BMC Cancer

Figure 4

From: Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition

Figure 4

Lack of superior antitumor activity of PLX3397 and PLX4032 in immunodeficient mice or with CD8+ T-cell depletion. a) Tumor growth curves of established SM1 tumors in NSG mice treated with PLX3397 and PLX4032. b) SM1 tumor-bearing mice treated with PLX3397 and PLX4032 received anti-CD8 depleting antibody. On day 16, the differences between vehicle and anti-CD8 depletion group: p = 0.15; anti-CD8 depletion group and triple combination: p = 0.0000001; triple combination and PLX4032: p = 0.0000001; PLX4032 and combo: p = 0.000006.

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