Figure 3
From: Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition
Changes in tumor infiltrating lymphocytes in responses to PLX3397 and PLX4032. a) C57BL/6 mice with SM1 tumors were treated with PLX3397 and PLX4032 for 5Â days. Tissue immunofluorescence microscopy of tumor sections was used to determine effect of the drugs on lymphocytes. Representative H&E (left) and immunofluorescence for lymphocytes stained with anti-CD8-FITC (green, right), and nuclei stained with DAPI (blue, right). b) Cells stained for CD3 were used for FACS analysis. Bar-graph representation of percentage of CD3+ T-cells in tumors. c) Representative FACS plots demonstrating percentages of CD3+ T-cells in tumor tissue.