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Figure 1 | BMC Cancer

Figure 1

From: Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition

Figure 1

Combined antitumor activity of PLX3397 and PLX4032 in murine melanoma SM1 model. a) Schematic of PLX3397 and PLX4032 treatments in C57BL/6 mice with previously established SM1 tumors. b) Tumor growth curves of established SM1 in C57BL/6 mice through day 28 post-tumor implantation. On day 12, the differences between vehicle and PLX3397: p = 0.0000004; PLX3397 and PLX4032: p = 0.000000009; PLX4032 and combo: p = 0.000001. c) Kaplan–Meier actuarial plot of time to mouse sacrifice due to large tumor burden or to study termination when tumor size was less than 14 mm in maximum diameter.

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