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Table 5 Clinical characteristics and treatment outcomes of patients with isolated CNS relapse

From: Risk factors and clinical outcomes of acute myeloid leukaemia with central nervous system involvement in adults

Patient Age (years) Gender FAB Leukocyte (/μL) Cytogenetics Initial CNS disease CNS Symptoms Radiation therapy* HSCT Time from remission to CNS relapse (months) Time from CNS relapse to BM relapse (months) Outcome after isolated CNS relapse
1 24 M M5 113510 t(9;11;13)(p22;q23;q34) Nil Headache No Yes 2 - CR in 41.6 m
2 28 M M4 172700 t(11;19)(q23;p13) Nil Tremor Yes No 14 5.8 Died in 7.4 m
3 28 F M4 123550 t(6;11)(q27;q23) Nil Dizziness No Yes 3.3 14.9# Died in 41.4 m
4 35 M M4 33510 CN Nil Blurred vision Yes Yes 3.2 2.3 Died in 5.8 m
  1. *All patients received intensive systemic chemotherapy and intrathecal chemotherapy.
  2. #Bone marrow relapses of this patient happened after hematopoietic stem cell transplantation.
  3. Abbreviation: F female, M male, FAB French-American-British, CN normal karyotype, CNS central nervous system, HSCT hematopoietic stem cell transplantation, BM bone marrow, CR complete remission, m month.