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Table 5 Clinical characteristics and treatment outcomes of patients with isolated CNS relapse

From: Risk factors and clinical outcomes of acute myeloid leukaemia with central nervous system involvement in adults

Patient

Age (years)

Gender

FAB

Leukocyte (/μL)

Cytogenetics

Initial CNS disease

CNS Symptoms

Radiation therapy*

HSCT

Time from remission to CNS relapse (months)

Time from CNS relapse to BM relapse (months)

Outcome after isolated CNS relapse

1

24

M

M5

113510

t(9;11;13)(p22;q23;q34)

Nil

Headache

No

Yes

2

-

CR in 41.6 m

2

28

M

M4

172700

t(11;19)(q23;p13)

Nil

Tremor

Yes

No

14

5.8

Died in 7.4 m

3

28

F

M4

123550

t(6;11)(q27;q23)

Nil

Dizziness

No

Yes

3.3

14.9#

Died in 41.4 m

4

35

M

M4

33510

CN

Nil

Blurred vision

Yes

Yes

3.2

2.3

Died in 5.8 m

  1. *All patients received intensive systemic chemotherapy and intrathecal chemotherapy.
  2. #Bone marrow relapses of this patient happened after hematopoietic stem cell transplantation.
  3. Abbreviation: F female, M male, FAB French-American-British, CN normal karyotype, CNS central nervous system, HSCT hematopoietic stem cell transplantation, BM bone marrow, CR complete remission, m month.