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Table 3 Univariate and multivariate analyses to identify the risk factors predictive of CNS involvement

From: Risk factors and clinical outcomes of acute myeloid leukaemia with central nervous system involvement in adults

Variable

Univariate analysis

Multivariate analysis

 

OR

95% CI

P value

OR

95% CI

P value

Age*

5.654

2.01-15.904

0.001

5.933

1.82-19.343

0.003

Sex

0.786

0.319-1.932

0.599

-

-

-

WBC†

4.069

1.616-10.244

0.003

3.136

1.083-9.078

0.035

Platelet§

2.303

0.755-7.026

0.143

2.804

0.799-9.837

0.107

LDH‡

1.931

0.688-5.425

0.212

-

-

-

FAB M4¶

3.143

1.266-7.803

0.014

2.023

0.646-6.341

0.227

inv(16) ∆

2.899

0.609-13.79

0.181

1.176

0.277-10.612

0.562

11q23 abnormalities#

9.307

2.615-33.123

0.001

5.548

1.208-25.489

0.028

  1. Only variables with P value < 0.2 in the univariate analysis were incorporated into the multivariate logistic regression analysis.
  2. *Age ≤ 45 y relative to age > 45 y.
  3. †WBC greater than or equal to 50,000/μL vs less than 50,000/μL.
  4. §Platelet greater than or equal to 30,000/μL vs less than 30,000/μL.
  5. ‡LDH greater than or equal to two times the upper limit of normal vs less than two times the upper limit of normal.
  6. ¶French-American-British M4 morphology vs others.
  7. ∆Inversion of chromosome 16 vs others.
  8. #chromosome translocations involving 11q23 vs others.
  9. Abbreviation: CNS, central nervous system; OR, odds ratio; CI, confidence interval; WBC, white blood cell; LDH, lactate dehydrogenase.