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Table 3 Univariate and multivariate analyses to identify the risk factors predictive of CNS involvement

From: Risk factors and clinical outcomes of acute myeloid leukaemia with central nervous system involvement in adults

Variable Univariate analysis Multivariate analysis
  OR 95% CI P value OR 95% CI P value
Age* 5.654 2.01-15.904 0.001 5.933 1.82-19.343 0.003
Sex 0.786 0.319-1.932 0.599 - - -
WBC† 4.069 1.616-10.244 0.003 3.136 1.083-9.078 0.035
Platelet§ 2.303 0.755-7.026 0.143 2.804 0.799-9.837 0.107
LDH‡ 1.931 0.688-5.425 0.212 - - -
FAB M4¶ 3.143 1.266-7.803 0.014 2.023 0.646-6.341 0.227
inv(16) 2.899 0.609-13.79 0.181 1.176 0.277-10.612 0.562
11q23 abnormalities# 9.307 2.615-33.123 0.001 5.548 1.208-25.489 0.028
  1. Only variables with P value < 0.2 in the univariate analysis were incorporated into the multivariate logistic regression analysis.
  2. *Age ≤ 45 y relative to age > 45 y.
  3. †WBC greater than or equal to 50,000/μL vs less than 50,000/μL.
  4. §Platelet greater than or equal to 30,000/μL vs less than 30,000/μL.
  5. ‡LDH greater than or equal to two times the upper limit of normal vs less than two times the upper limit of normal.
  6. ¶French-American-British M4 morphology vs others.
  7. Inversion of chromosome 16 vs others.
  8. #chromosome translocations involving 11q23 vs others.
  9. Abbreviation: CNS, central nervous system; OR, odds ratio; CI, confidence interval; WBC, white blood cell; LDH, lactate dehydrogenase.