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Table 1 Comparison of clinical and laboratory characteristics of patients with and without CNS involvement

From: Risk factors and clinical outcomes of acute myeloid leukaemia with central nervous system involvement in adults

Variables Total (n = 395) Patients with CNS involvement (n = 20) Patients without CNS involvement (n = 375) Pvalue
Sex    0.648
Male 220 10(50) 210(56)  
Female 175 10(50) 165(44)  
Age (year) 53(18-90) 37.5(21-72) 54(18-90) <0.001
Laboratory data    
WBC (/μL) 21950(120-423000) 83865(1860-277250) 21050(120-423000) 0.003
Haemoglobin (g/dL) 8.1(2.9-14.5) 8.1(4.9-14.5) 8.1(2.9-14) 0.392
Platelet (×1,000 /μL) 45(1-802) 71.5(11-255) 44(1-802) 0.03
PBC (/μL) 9014(0-369070) 42751(0-260615) 8360(0-369070) 0.009
LDH (U/L) 859(206-13130) 1641.5(265-8693) 842(206-13130) 0.069
FAB    
M0 11 0(0) 11(2.9) >0.999
M1 85 4(20) 81(21.6) >0.999
M2 139 3(15) 136(36.3) 0.057
M4 116 11(55) 105(28) 0.02
M5 20 1(5) 19(5.1) >0.999
M6 15 0(0) 15(4) >0.999
Undetermined 9 1(5) 8(2.1) 0.377
  1. †number of patients (%).
  2. ‡median (range).
  3. Abbreviation: CNS central nervous system, WBC white blood cell, PBC peripheral blast cell, LDH lactate dehydrogenase, FAB French-American-British.