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Table 1 Comparison of clinical and laboratory characteristics of patients with and without CNS involvement

From: Risk factors and clinical outcomes of acute myeloid leukaemia with central nervous system involvement in adults

Variables

Total (n = 395)

Patients with CNS involvement (n = 20)

Patients without CNS involvement (n = 375)

Pvalue

Sex†

   

0.648

Male

220

10(50)

210(56)

 

Female

175

10(50)

165(44)

 

Age (year)‡

53(18-90)

37.5(21-72)

54(18-90)

<0.001

Laboratory data‡

    

WBC (/μL)

21950(120-423000)

83865(1860-277250)

21050(120-423000)

0.003

Haemoglobin (g/dL)

8.1(2.9-14.5)

8.1(4.9-14.5)

8.1(2.9-14)

0.392

Platelet (×1,000 /μL)

45(1-802)

71.5(11-255)

44(1-802)

0.03

PBC (/μL)

9014(0-369070)

42751(0-260615)

8360(0-369070)

0.009

LDH (U/L)

859(206-13130)

1641.5(265-8693)

842(206-13130)

0.069

FAB†

    

M0

11

0(0)

11(2.9)

>0.999

M1

85

4(20)

81(21.6)

>0.999

M2

139

3(15)

136(36.3)

0.057

M4

116

11(55)

105(28)

0.02

M5

20

1(5)

19(5.1)

>0.999

M6

15

0(0)

15(4)

>0.999

Undetermined

9

1(5)

8(2.1)

0.377

  1. †number of patients (%).
  2. ‡median (range).
  3. Abbreviation: CNS central nervous system, WBC white blood cell, PBC peripheral blast cell, LDH lactate dehydrogenase, FAB French-American-British.