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Table 3 Univariate and multivariate analyses of different prognostic factors in 1148 patients with gastric carcinoma for disease-free survival

From: The prognostic significance of lymphovascular invasion in patients with resectable gastric cancer: a large retrospective study from Southern China

Variable Univariate analysis* Multivariate analysis
All cases HR (95% CI) P value HR (95% CI) P value
Sex    0.936   
  Female 354 Reference    
  Male 794 1.007 (0.851-1.192)    
Age at diagnosis (years)    0.359   
  ≤59 574 Reference    
  >59 574 1.075 (0.921-1.255)    
CEA    0.068   
  Normal 791 Reference    
  Elevated 157 1.227 (0.985-1.528)    
CA19-9    <0.0001 1.145 (0.929-1.411) 0.204
  Normal 707 Reference    
  Elevated 195 1.499 (1.221-1.840)    
Size (diameter), cm    <0.0001 1.334 (1.111-1.602) 0.002
  ≤5 697 Reference    
  >5 451 1.643 (1.407-1.919)    
Lauren classification    0.001 0.821 (0.619-1.090) 0.173
  Diffuse 585 Reference    
  Mixed/ Intestinal 563 0.768 (0.657-0.897)    
Differentiation    <0.0001 1.085 (0.801-1.470) 0.598
  Well/moderate 435 Reference    
  Poor/undifferentiated 713 1.374 (1.166-1.618)    
Gastric wall invasion    <0.0001 2.164 (1.416-3.308) <0.0001
  T1/T2 150 Reference    
  T3/T4 998 4.450 (3.083-6.424)    
Nodal metastasis    <0.0001 0.788 (0.571-1.088) 0.148
  N0 377 Reference    
  N1-N3 771 2.545 (2.106-3.075)    
Distant metastasis    <0.0001 2.259 (1.785-2.858) <0.0001
  M0 1003 Reference    
  M1 145 3.544 (2.906-4.321)    
TNM stage    <0.0001 2.234 (1.596-3.127) <0.0001
  I/II 486 Reference    
  III/ IV 662 3.062 (2.570-3.649)    
Lymphovascular invasion    <0.0001 1.393 (1.150-1.688) 0.001
  Absent 744 Reference    
  Present 404 2.046 (1.749-2.394)    
  1. *Cox regression model; Preoperative serum CEA was measured in 948 patients; Preoperative serum CA19-9 was measured in 902 patients; HR indicates hazards ratio; CI indicates confidence interval; CEA indicates carcinoembryonic antigen; CA19-9 indicates carbohydrate antigen 19-9.