Variable | Univariate analysis* | Multivariate analysis | |||
---|---|---|---|---|---|
All cases | HR (95% CI) | P value | HR (95% CI) | P value | |
Sex | Â | Â | 0.800 | Â | Â |
  Female | 354 | Reference |  |  |  |
  Male | 794 | 0.977 (0.817-1.169) |  |  |  |
Age at diagnosis (years) | Â | Â | 0.046 | 1.170 (0.960-1.425) | 0.120 |
  ≤59 | 574 | Reference |  |  |  |
  >59 | 574 | 1.184 (1.003-1.398) |  |  |  |
CEA†|  |  | 0.082 |  |  |
  Normal | 791 | Reference |  |  |  |
  Elevated | 157 | 1.231 (0.974-1.556) |  |  |  |
CA19-9‡ |  |  | 0.001 | 1.098 (0.878-1.374) | 0.411 |
  Normal | 707 | Reference |  |  |  |
  Elevated | 195 | 1.438 (1.155-1.791) |  |  |  |
Size (diameter), cm | Â | Â | <0.0001 | 1.311 (1.077-1.595) | 0.007 |
  ≤5 | 697 | Reference |  |  |  |
  >5 | 451 | 1.695 (1.436-2.000) |  |  |  |
Lauren classification | Â | Â | <0.0001 | 0.836 (0.619-1.129) | 0.243 |
  Diffuse | 585 | Reference |  |  |  |
  Mixed/ Intestinal | 563 | 0.740 (0.627-0.875) |  |  |  |
Differentiation | Â | Â | <0.0001 | 1.126 (0.816-1.554) | 0.471 |
  Well/moderate | 435 | Reference |  |  |  |
  Poor/undifferentiated | 713 | 1.445 (1.211-1.724) |  |  |  |
Gastric wall invasion | Â | Â | <0.0001 | 2.284 (1.413-3.691) | 0.001 |
  T1/T2 | 150 | Reference |  |  |  |
  T3/T4 | 998 | 4.643 (3.083-6.991) |  |  |  |
Nodal metastasis | Â | Â | <0.0001 | 0.806 (0.573-1.134) | 0.216 |
  N0 | 377 | Reference |  |  |  |
  N1-N3 | 771 | 2.529 (2.061-3.102) |  |  |  |
Distant metastasis | Â | Â | <0.0001 | 2.365 (1.851-3.022) | <0.0001 |
  M0 | 1003 | Reference |  |  |  |
  M1 | 145 | 3.479 (2.832-4.272) |  |  |  |
TNM stage | Â | Â | <0.0001 | 2.090 (1.462-2.988) | <0.0001 |
  I/II | 486 | Reference |  |  |  |
  III/ IV | 662 | 3.039 (2.516-3.670) |  |  |  |
Vascular invasion | Â | Â | <0.0001 | 1.438 (1.171-1.766) | 0.001 |
  Absent | 744 | Reference |  |  |  |
  Present | 404 | 2.121 (1.795-2.506) |  |  |  |