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Table 2 Univariate and multivariate analyses of different prognostic factors in 1148 patients with gastric carcinoma for disease-specific survival

From: The prognostic significance of lymphovascular invasion in patients with resectable gastric cancer: a large retrospective study from Southern China

Variable Univariate analysis* Multivariate analysis
All cases HR (95% CI) P value HR (95% CI) P value
Sex    0.800   
  Female 354 Reference    
  Male 794 0.977 (0.817-1.169)    
Age at diagnosis (years)    0.046 1.170 (0.960-1.425) 0.120
  ≤59 574 Reference    
  >59 574 1.184 (1.003-1.398)    
CEA    0.082   
  Normal 791 Reference    
  Elevated 157 1.231 (0.974-1.556)    
CA19-9    0.001 1.098 (0.878-1.374) 0.411
  Normal 707 Reference    
  Elevated 195 1.438 (1.155-1.791)    
Size (diameter), cm    <0.0001 1.311 (1.077-1.595) 0.007
  ≤5 697 Reference    
  >5 451 1.695 (1.436-2.000)    
Lauren classification    <0.0001 0.836 (0.619-1.129) 0.243
  Diffuse 585 Reference    
  Mixed/ Intestinal 563 0.740 (0.627-0.875)    
Differentiation    <0.0001 1.126 (0.816-1.554) 0.471
  Well/moderate 435 Reference    
  Poor/undifferentiated 713 1.445 (1.211-1.724)    
Gastric wall invasion    <0.0001 2.284 (1.413-3.691) 0.001
  T1/T2 150 Reference    
  T3/T4 998 4.643 (3.083-6.991)    
Nodal metastasis    <0.0001 0.806 (0.573-1.134) 0.216
  N0 377 Reference    
  N1-N3 771 2.529 (2.061-3.102)    
Distant metastasis    <0.0001 2.365 (1.851-3.022) <0.0001
  M0 1003 Reference    
  M1 145 3.479 (2.832-4.272)    
TNM stage    <0.0001 2.090 (1.462-2.988) <0.0001
  I/II 486 Reference    
  III/ IV 662 3.039 (2.516-3.670)    
Vascular invasion    <0.0001 1.438 (1.171-1.766) 0.001
  Absent 744 Reference    
  Present 404 2.121 (1.795-2.506)    
  1. *Cox regression model; Preoperative serum CEA was measured in 948 patients; Preoperative serum CA19-9 was measured in 902 patients; HR indicates hazards ratio; CI indicates confidence interval; CEA indicates carcinoembryonic antigen; CA19-9 indicates carbohydrate antigen 19-9.