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Table 4 Predictive factors for overall survival of UTUC patients after RNU

From: High expression of KPNA2 defines poor prognosis in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy

Variable Characteristics Univariate Multivariate
HR (95%CI) P value HR (95%CI) P value
Age (y) ≥70 vs <70 1.036 (0.981-1.095) 0.207   
Sex Male vs female 4.195 (1.631-10.789) 0.003 4.155 (1.771-9.747) 0.001
BMI (kg/m2) ≥25 vs <25 0.933 (0.373-2.334) 0.882   
Tumor side Left vs Right 0.482 (0.172-1.356) 0.167   
Tumor location Ureter vs Pelvis 2.026 (0.524-7.836) 0.306   
Tumor multiplicity Multiple vs Single 1.041 (0.398-2.724) 0.935   
Tumor size (cm) ≥3.5 vs <3.5 4.245 (1.526-11.803) 0.006 3.680 (1.495-9.056) 0.005
Tumor configuration Nonpapillary vs Papillary 1.860 (0.676-5.116) 0.229   
T stage T2-T4 vs Ta-T1 4.172 (1.601-10.535) 0.004 4.035 (1.678-9.521) 0.001
G grade High vs Low 0.932 (0.360-2.411) 0.885   
eGFR (ml/min/1.73 m2) <60 vs ≥60 1.247 (0.439-3.538) 0.678   
Hydronephrosis Present vs Absent 1.081 (0.294-3.981) 0.907   
Lymph node stage N+ vs N0 3.206 (0.715-14.378) 0.128   
KPNA2 expression High vs Low 3.443 (1.271-9.329) 0.015 4.480 (1.844-10.887) 0.001
  1. HR, hazard radio; CI, confidence interval; BMI, body mass index; eGFR, estimated glomerular filtration rate.