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Table 2 Predictive factors for bladder recurrence in UTUC patients after RNU

From: High expression of KPNA2 defines poor prognosis in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy

Variable

Characteristics

Univariate

Multivariate

HR (95%CI)

P value

HR (95%CI)

P value

Age (y)

≥70 vs <70

0.969 (0.941-0.999)

0.042*

0.977 (0.953-1.003)

0.080

Sex

Male vs female

2.077 (1.157-3.729)

0.014*

1.980 (1.127-3.480)

0.017

BMI (kg/m2)

≥25 vs <25

0.791 (0.429-1.458)

0.452

  

Tumor side

Left vs Right

1.853 (1.010-3.401)

0.046*

1.732 (0.984-3.049)

0.057

Tumor location

Ureter vs Pelvis

2.873 (1.342-6.151)

0.007

2.020 (1.147-3.560)

0.015

Tumor multiplicity

Multiple vs Single

2.770 (1.521-5.046)

0.001

2.431 (1.388-4.261)

0.002

Tumor size (cm)

≥3.5 vs <3.5

0.590 (0.311-1.119)

0.106

  

Tumor configuration

Nonpapillary vs Papillary

0.592 (0.260-1.350)

0.212

  

T stage

T2-T4 vs Ta-T1

0.951 (0.938-0.986)

0.039

0.970 (0.949-1.001)

0.075

G grade

High vs Low

0.696 (0.362-1.337)

0.277

  

eGFR (ml/min/1.73 m2)

<60 vs ≥60

0.752 (0.397-1.422)

0.380

  

Hydronephrosis

Present vs Absent

0.595 (0.270-1.309)

0.197

  

Lymph node stage

N+ vs N0

0.226 (0.029-1.791)

0.159

  

KPNA2 expression

High vs Low

3.052 (1.600-5.822)

0.001

2.017 (1.126-3.612)

0.018

  1. HR, hazard radio; CI, confidence interval; BMI, body mass index; eGFR, estimated glomerular filtration rate.