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Table 2 Predictive factors for bladder recurrence in UTUC patients after RNU

From: High expression of KPNA2 defines poor prognosis in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy

Variable Characteristics Univariate Multivariate
HR (95%CI) P value HR (95%CI) P value
Age (y) ≥70 vs <70 0.969 (0.941-0.999) 0.042* 0.977 (0.953-1.003) 0.080
Sex Male vs female 2.077 (1.157-3.729) 0.014* 1.980 (1.127-3.480) 0.017
BMI (kg/m2) ≥25 vs <25 0.791 (0.429-1.458) 0.452   
Tumor side Left vs Right 1.853 (1.010-3.401) 0.046* 1.732 (0.984-3.049) 0.057
Tumor location Ureter vs Pelvis 2.873 (1.342-6.151) 0.007 2.020 (1.147-3.560) 0.015
Tumor multiplicity Multiple vs Single 2.770 (1.521-5.046) 0.001 2.431 (1.388-4.261) 0.002
Tumor size (cm) ≥3.5 vs <3.5 0.590 (0.311-1.119) 0.106   
Tumor configuration Nonpapillary vs Papillary 0.592 (0.260-1.350) 0.212   
T stage T2-T4 vs Ta-T1 0.951 (0.938-0.986) 0.039 0.970 (0.949-1.001) 0.075
G grade High vs Low 0.696 (0.362-1.337) 0.277   
eGFR (ml/min/1.73 m2) <60 vs ≥60 0.752 (0.397-1.422) 0.380   
Hydronephrosis Present vs Absent 0.595 (0.270-1.309) 0.197   
Lymph node stage N+ vs N0 0.226 (0.029-1.791) 0.159   
KPNA2 expression High vs Low 3.052 (1.600-5.822) 0.001 2.017 (1.126-3.612) 0.018
  1. HR, hazard radio; CI, confidence interval; BMI, body mass index; eGFR, estimated glomerular filtration rate.