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Table 1 Correlation between KPNA2 expression and clinicopathologic characteristics of UTUC patients after RNU

From: High expression of KPNA2 defines poor prognosis in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy

 

KPNA2 immunoreactivity

Variable

Case No.

Low (N = 101)

High (N = 75)

P *

Sex

   

0.038

  Male

78

48

30

 

  Female

98

53

45

 

Age (y)

   

0.95

  ≥70

84

48

36

 

  <70

92

53

39

 

BMI (kg/m2)

   

0.26

  >27

37

24

13

 

  27-22

81

46

35

 

  <22

58

31

27

 

Tumor size (cm)

   

0.46

  ≥3.5

81

41

40

 

  <3.5

95

60

35

 

T stage

   

<0.001

  Ta-T1

61

48

13

 

  T2

70

36

34

 

  T3

42

17

25

 

  T4

3

0

3

 

Pathologic lymph node stage

   

0.25

  N0

168

98

70

 

  N+

8

3

5

 

G grade

   

<0.001

  G1

3

3

0

 

  G2

105

77

28

 

  G3

68

21

47

 

eGFR (ml/min/1.73 m2)#

   

0.83

  ≥60

77

48

29

 

  60-15

90

49

41

 

  <15

9

4

5

 

Hydronephrosis

   

0.24

  Absent

70

46

24

 

  Present

106

65

41

 

Location

   

0.30

 

81

50

31

 

  Renal pelvis Proximal

6

5

1

 

  Middle

17

9

8

 

  Distal ureter

52

26

26

 

  Multiple

20

11

9

 

Side

   

0.95

  Left

82

49

33

 

  Right

94

52

42

 

Tumor multiplicity

   

0.99

  Single tumor focus

121

69

52

 

  Multiple tumor foci

55

32

23

 

Tumor configuration

   

0.53

  Papillary

140

82

58

 

  Nonpapillary

36

19

17

 
  1. *Mann–Whitney test for the comparison between two groups or Kruskal-Wallis test for more than two groups.
  2. # Estimated glomerular filtration rate (eGFR) was calculated using the re-expressed Modification of Diet in Renal Disease (MDRD) formulas for the Chinese population.