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Table 1 Correlation between KPNA2 expression and clinicopathologic characteristics of UTUC patients after RNU

From: High expression of KPNA2 defines poor prognosis in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy

  KPNA2 immunoreactivity
Variable Case No. Low (N = 101) High (N = 75) P *
Sex     0.038
  Male 78 48 30  
  Female 98 53 45  
Age (y)     0.95
  ≥70 84 48 36  
  <70 92 53 39  
BMI (kg/m2)     0.26
  >27 37 24 13  
  27-22 81 46 35  
  <22 58 31 27  
Tumor size (cm)     0.46
  ≥3.5 81 41 40  
  <3.5 95 60 35  
T stage     <0.001
  Ta-T1 61 48 13  
  T2 70 36 34  
  T3 42 17 25  
  T4 3 0 3  
Pathologic lymph node stage     0.25
  N0 168 98 70  
  N+ 8 3 5  
G grade     <0.001
  G1 3 3 0  
  G2 105 77 28  
  G3 68 21 47  
eGFR (ml/min/1.73 m2)#     0.83
  ≥60 77 48 29  
  60-15 90 49 41  
  <15 9 4 5  
Hydronephrosis     0.24
  Absent 70 46 24  
  Present 106 65 41  
Location     0.30
  81 50 31  
  Renal pelvis Proximal 6 5 1  
  Middle 17 9 8  
  Distal ureter 52 26 26  
  Multiple 20 11 9  
Side     0.95
  Left 82 49 33  
  Right 94 52 42  
Tumor multiplicity     0.99
  Single tumor focus 121 69 52  
  Multiple tumor foci 55 32 23  
Tumor configuration     0.53
  Papillary 140 82 58  
  Nonpapillary 36 19 17  
  1. *Mann–Whitney test for the comparison between two groups or Kruskal-Wallis test for more than two groups.
  2. # Estimated glomerular filtration rate (eGFR) was calculated using the re-expressed Modification of Diet in Renal Disease (MDRD) formulas for the Chinese population.