Figure 4
From: Transient elevation of glycolysis confers radio-resistance by facilitating DNA repair in cells
Glycolytic inhibitors reverse MRMs induced radio-resistance. Inhibition of glycolysis by 2-DG (5 mM), 3-BP (5 μM) and fasentin (25 μM) followed by DNP treatment before irradiation (5 Gy) reverses glycolysis induced radio-resistance in BMG-1 cells (A). Both DNP and inhibitors of glycolysis/ glucose transporter were added simultaneously before irradiation. Inhibition of mitochondrial respiration without up-regulating glycolysis (using 5 μg/ ml Antimycin A) does not confer radio-resistance in BMG-1 cells (B). The data shown are the mean values (±1 SD) of nine observations from three independent experiments. Differences were statistically significant (*p < 0.05).