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Figure 3 | BMC Cancer

Figure 3

From: Transient elevation of glycolysis confers radio-resistance by facilitating DNA repair in cells

Figure 3

MRMs induces radio-resistance. Enhanced radio-resistance (clonogenic survival; macro-colony assay) observed due to MRMs (PS3, DNP and MB) induced glycolysis in BMG-1 (A), OCT-1 (B) and HEK293 (C). The figure (D) represents the dose response curve of BMG-1, OCT-1 and HEK293 cells against radiation in DNP and vehicle treated cells. The concentrations of MRMs used were as follows, PS3, 25 μg/ml; DNP, 1 μM; MB, 25 μM. After treatment cells were incubated for 4 hours in liquid holding before plating for macro colony formation. Surviving fraction of un-irradiated and irradiated samples was calculated by considering the plating efficiency of un-irradiated control as 1. The data shown are the mean values (±1 SD) of nine observations from three independent experiments. Statistical significance *p < 0.05.

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