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Table 3 Treatment outcomes according to genes expression levels

From: Effects of JWA, XRCC1 and BRCA1 mRNA expression on molecular staging for personalized therapy in patients with advanced esophageal squamous cell carcinoma

 

RR, N (%)

mOS (months)

Gene

Level

No.

CR + PR

SD + PD

P value

Median (95% CI)

P value

JWA

Low

73

68.5

31.5

 

8.0(6.6-9.4)

 
 

High

72

83.3

16.7

0.052

19.0(15.8-22.2)

<0.001

XRCC1

Low

73

68.5

31.5

 

9.0(7.5-10.5)

 
 

High

72

83.3

16.7

0.052

19.0(15.4-22.6)

<0.001

BRCA1

Low

74

79.7

20.3

 

15.0(14.4-17.6)

 
 

High

71

71.8

28.2

0.267

14.0(11.5-14.5)

0.429

  1. mOS = median overall survival; RR = response rate; CI = confidence interval; CR = complete response; PR = partial response; SD = stable disease; PD = progress disease.
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BMC Cancer

ISSN: 1471-2407

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