Effects of JWA, XRCC1 and BRCA1 mRNA expression on molecular staging for personalized therapy in patients with advanced esophageal squamous cell carcinoma

Table 2 Clinical characteristics associated with JWA, XRCC1 and BRCA1 mRNA expression levels

	JWA level			XRCC1 level			BRCA1 level			Overall survival
Characteristics	Low	High	P value	Low	High	P value	Low	High	P value	mOS (95%CI)	P value
Age, y
≤62	39	36		40	35		37	38		13.0(11.3-14.8)
>62	34	36	0.741	33	37	0.456	37	33	0.671	13.0(10.0-16.0)	0.805
Gender
Males	53	39		52	40		47	45		12.0(10.1-13.9)
Females	20	33	0.025	21	32	0.053	27	26	0.987	16.0(13.4-18.6)	0.007
ECOG, PS
0-1	66	67		68	65		67	66		14.0(12.3-15.4)
2	6	6	0.98	5	7	0.53	7	5	0.597	6.0(4.9-7.8)	<0.001
TNM stage
II	12	16		14	14		18	10		14.0(11.9-16.1)
III	25	22		25	22		22	25		10.0(8.3-11.7)	0.096
IV	36	34	0.666	34	36	0.886	34	36	0.290	14.0(11.4-14.6)	0.656
G stage
G1	5	15		7	13		9	11		18.5(15.8-21.2)
G2	48	42		47	43		50	40		13.0(11.4-14.7)	0.061
G3	20	15	0.047	19	16	0.328	15	20	0.375	9.0(6.7-11.3)	0.005

mOS = median overall survival; y = years; G = differentiation grade; ECOG = Eastern Cooperative Oncology Group; PS = performance status.

ISSN: 1471-2407