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Table 2 Clinical characteristics associated with JWA, XRCC1 and BRCA1 mRNA expression levels

From: Effects of JWA, XRCC1 and BRCA1 mRNA expression on molecular staging for personalized therapy in patients with advanced esophageal squamous cell carcinoma

  JWA level XRCC1 level BRCA1 level Overall survival
Characteristics Low High P value Low High P value Low High P value mOS (95%CI) P value
Age, y            
≤62 39 36   40 35   37 38   13.0(11.3-14.8)  
>62 34 36 0.741 33 37 0.456 37 33 0.671 13.0(10.0-16.0) 0.805
Gender            
Males 53 39   52 40   47 45   12.0(10.1-13.9)  
Females 20 33 0.025 21 32 0.053 27 26 0.987 16.0(13.4-18.6) 0.007
ECOG, PS            
0-1 66 67   68 65   67 66   14.0(12.3-15.4)  
2 6 6 0.98 5 7 0.53 7 5 0.597 6.0(4.9-7.8) <0.001
TNM stage            
II 12 16   14 14   18 10   14.0(11.9-16.1)  
III 25 22   25 22   22 25   10.0(8.3-11.7) 0.096
IV 36 34 0.666 34 36 0.886 34 36 0.290 14.0(11.4-14.6) 0.656
G stage            
G1 5 15   7 13   9 11   18.5(15.8-21.2)  
G2 48 42   47 43   50 40   13.0(11.4-14.7) 0.061
G3 20 15 0.047 19 16 0.328 15 20 0.375 9.0(6.7-11.3) 0.005
  1. mOS = median overall survival; y = years; G = differentiation grade; ECOG = Eastern Cooperative Oncology Group; PS = performance status.