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Table 3 Comparison of patient tumors with primary cell culture and with patient derived xenograft in terms of BAP1 mutation and CDKN2A deletion

From: Mesothelioma patient derived tumor xenografts with defined BAP1 mutations that mimic the molecular characteristics of human malignant mesothelioma

BAP1mutation CDKN2Adeletion by FISH
  Patient tumor Primary cell culture Mouse xenograft   Patient tumor Primary cell culture Mouse xenograft
NCI-Meso16 (splice site mutation in Intron 4) Present Present Present NCI-Meso16 (wt) Homozygous deleted cells some wt cells Mostly wt. Some homozygous deleted cells Mostly wt. Some homozygous deleted cells
NCI-Meso17 (5 bp deletion in intron 15- Exon 16 junction) Present Present Present NCI-Meso17 (Homozygous deletion) Present Present Present
NCI-Meso18 (large deletion) Sample not available large deletion Does not form tumor NCI-Meso18 (Homozygous deletion) Sample not available Present Does not form tumor
NCI-Meso19 (Wt) Wt Wt Does not form tumor NCI-Meso19 (Homozygous deletion) Present Present Does not form tumor
NCI-Meso21 (20 bp deletion in Exon 13) Sample not available Present Present NCI-Meso21 (Heterozygous deletion) Sample not available Present Present
  1. Wt- wild-type.