Skip to main content

Table 3 Comparison of patient tumors with primary cell culture and with patient derived xenograft in terms of BAP1 mutation and CDKN2A deletion

From: Mesothelioma patient derived tumor xenografts with defined BAP1 mutations that mimic the molecular characteristics of human malignant mesothelioma

BAP1mutation

CDKN2Adeletion by FISH

 

Patient tumor

Primary cell culture

Mouse xenograft

 

Patient tumor

Primary cell culture

Mouse xenograft

NCI-Meso16 (splice site mutation in Intron 4)

Present

Present

Present

NCI-Meso16 (wt)

Homozygous deleted cells some wt cells

Mostly wt. Some homozygous deleted cells

Mostly wt. Some homozygous deleted cells

NCI-Meso17 (5 bp deletion in intron 15- Exon 16 junction)

Present

Present

Present

NCI-Meso17 (Homozygous deletion)

Present

Present

Present

NCI-Meso18 (large deletion)

Sample not available

large deletion

Does not form tumor

NCI-Meso18 (Homozygous deletion)

Sample not available

Present

Does not form tumor

NCI-Meso19 (Wt)

Wt

Wt

Does not form tumor

NCI-Meso19 (Homozygous deletion)

Present

Present

Does not form tumor

NCI-Meso21 (20 bp deletion in Exon 13)

Sample not available

Present

Present

NCI-Meso21 (Heterozygous deletion)

Sample not available

Present

Present

  1. Wt- wild-type.