BAP1mutation | CDKN2Adeletion by FISH | ||||||
---|---|---|---|---|---|---|---|
 | Patient tumor | Primary cell culture | Mouse xenograft |  | Patient tumor | Primary cell culture | Mouse xenograft |
NCI-Meso16 (splice site mutation in Intron 4) | Present | Present | Present | NCI-Meso16 (wt) | Homozygous deleted cells some wt cells | Mostly wt. Some homozygous deleted cells | Mostly wt. Some homozygous deleted cells |
NCI-Meso17 (5Â bp deletion in intron 15- Exon 16 junction) | Present | Present | Present | NCI-Meso17 (Homozygous deletion) | Present | Present | Present |
NCI-Meso18 (large deletion) | Sample not available | large deletion | Does not form tumor | NCI-Meso18 (Homozygous deletion) | Sample not available | Present | Does not form tumor |
NCI-Meso19 (Wt) | Wt | Wt | Does not form tumor | NCI-Meso19 (Homozygous deletion) | Present | Present | Does not form tumor |
NCI-Meso21 (20Â bp deletion in Exon 13) | Sample not available | Present | Present | NCI-Meso21 (Heterozygous deletion) | Sample not available | Present | Present |