BMC Cancer

Table 2 Mutations in early passage malignant mesothelioma primary cell cultures

From: Mesothelioma patient derived tumor xenografts with defined BAP1 mutations that mimic the molecular characteristics of human malignant mesothelioma

Cell lines	CDKN2Adeletion	BAP1	NF2	TP53	EGFR	KRAS	NRAS	BRAF	PIK3 CA	ERBB2	AKT1
NCI-Meso16	wt	Intron 4 spice site mutation c.256-2A > G, Hm	Wt	Wt	Wt	Wt	Wt	Wt	Wt	Wt	Wt
NCI-Meso17	Hm	Deletion of CAGAT at intron 15/exon 16 junction. c.	Wt	Wt	Wt	Wt	Wt	Wt	Wt	Wt	Wt
NCI-Meso17	Hm	1984-3_1985delCAGAT	Wt	Wt	Wt	Wt	Wt	Wt	Wt	Wt	Wt
NCI-Meso18	Hm	Large deletion	Wt	Wt	Wt	Wt	Wt	Wt	Wt	Wt	Wt
NCI-Meso19	Hm	Wt	Large deletion	*P322S	Wt	Wt	Wt	Wt	Wt	Wt	Wt
NCI-Meso21	Hz	Homozygous 20 bp deletion in exon 13. c.	Wt	Wt	Wt	Wt	Wt	Wt	Wt	Wt	Wt
NCI-Meso21	Hz	1302_1321delTGGGCAA CTGTCAGTGCTGC	Wt	Wt	Wt	Wt	Wt	Wt	Wt	Wt	Wt

All 5 cell lines were analyzed for mutations in BAP1 whole gene, P53 exons 2–9, EGFR Exons 18–24, KRAS and NRAS Codon 12, 13 and 61, BRAF-599-601, PIK3CA Exon 9 and 20, ERBB2 insertion in Exon 20 and AKT1 codon 17. *TP53 heterozygous mis-sense mutation in codon 322 (P322S, Exon 9), polymorphism codon 72 (P72R, Exon 4). Hm, homozygous. Hz, heterozygous. Wt, wild-type.

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ISSN: 1471-2407

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