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Table 2 Mutations in early passage malignant mesothelioma primary cell cultures

From: Mesothelioma patient derived tumor xenografts with defined BAP1 mutations that mimic the molecular characteristics of human malignant mesothelioma

Cell lines CDKN2Adeletion BAP1 NF2 TP53 EGFR KRAS NRAS BRAF PIK3 CA ERBB2 AKT1
NCI-Meso16 wt Intron 4 spice site mutation c.256-2A > G, Hm Wt Wt Wt Wt Wt Wt Wt Wt Wt
NCI-Meso17 Hm Deletion of CAGAT at intron 15/exon 16 junction. c. Wt Wt Wt Wt Wt Wt Wt Wt Wt
1984-3_1985delCAGAT
NCI-Meso18 Hm Large deletion Wt Wt Wt Wt Wt Wt Wt Wt Wt
NCI-Meso19 Hm Wt Large deletion *P322S Wt Wt Wt Wt Wt Wt Wt
NCI-Meso21 Hz Homozygous 20 bp deletion in exon 13. c. Wt Wt Wt Wt Wt Wt Wt Wt Wt
1302_1321delTGGGCAA CTGTCAGTGCTGC
  1. All 5 cell lines were analyzed for mutations in BAP1 whole gene, P53 exons 2–9, EGFR Exons 18–24, KRAS and NRAS Codon 12, 13 and 61, BRAF-599-601, PIK3CA Exon 9 and 20, ERBB2 insertion in Exon 20 and AKT1 codon 17. *TP53 heterozygous mis-sense mutation in codon 322 (P322S, Exon 9), polymorphism codon 72 (P72R, Exon 4). Hm, homozygous. Hz, heterozygous. Wt, wild-type.
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BMC Cancer

ISSN: 1471-2407

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