Figure 9
From: Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis
Addition of PAK1 inhibitor to KRAS prenylation inhibitors alters the proliferation of NSCLC cells. Line charts demonstrating mean cell count of H157 and A549 cells upon exposure to prenylation inhibitors [FTI (BMS-225975) and GGTI (P61A6) at 500 nM each], PAK1 inhibitor (FRAX1036 at 10 μM) or combination in comparison to cells exposed to inhibitors’ diluent (DMSO).