Figure 8
From: Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis
Addition of PAK1 inhibitor to KRAS prenylation inhibitors dephosphorylated ERK. Western blots demonstrate ERK dephosphorylation following 24 hour exposure of Rh2 cells to (F) farnesyltransferase inhibitor (BMS-225975 at 2 μM), (G) geranylgeranyltransferase inhibitor (P61A6 at 2 μM), combination of the two (F + G), or (F + G) along with PAK1 inhibitor (FRAX597 at 40 μM).