Figure 7
From: Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis
Addition of PAK1 inhibitor to KRAS prenylation inhibitors dramatically alters cell morphology and motility. Photomicrographs of standard wound healing assays in H157 and A549 cells (KRAS mutant). Cells were exposed to (i) farnesyltransferase inhibitor (BMS-225975 at 2 μM) and geranylgeranyltransferase inhibitor (P61A6 at 2 μM) [F + G]; (ii) PAK1 inhibitor (IPA-3 at 5 μM); (iii) combination of the three inhibitors or (iv) the inhibitor vehicles for 24-48 hours.