Figure 2

PAK1 activation and Crk phosphorylation are positively correlated while establish a negative correlation with E-cadherin in NSCLC. Dot plots demonstrating the correlation between A-E-cadherin and p-PAK1(Thr423); B-E-cadherin and p-Crk-II(Ser41); C-p-PAK1(Thr423) and p-Crk-II(Ser41) expression by immunohistochemistry in 17 NSCLC clinical specimens. The average intensity of protein expression across the slide is quantified in a scale from 0-3+. The correlation between the expressions of each two marker was examined by utilizing Spearman Rank Correlation statistical test.