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Fig. 1 | BMC Cancer

Fig. 1

From: microRNA-34a inhibits epithelial mesenchymal transition in human cholangiocarcinoma by targeting Smad4 through transforming growth factor-beta/Smad pathway

Fig. 1

miR-34a expression in human EHCC tissues and CC cell lines, and the relationship between miR-34a expression and disease-free survival in EHCC patients. a The mRNA expression profile of miR-34a in 27 primary EHCC tissues compared to the adjacent non-tumor tissues and 7 normal bile duct tissues (NBD) determined by qRT-PCR (***P < 0.01). U6 was used as the internal control. b The mRNA expression level of miR-34a in 4 CC cell lines (QBC939, HuCCT1, RBE and HCCC9810) compared to HiBECs determined by qRT-PCR (***P < 0.01). U6 was used as the internal control. c miR-34a predicts disease-free survival in EHCC patients. The Kaplan-Meier curve of disease-free survival in patients with high miR-34a expression (n = 13) and low miR-34a expression (n = 14) (***P < 0.01). The median disease-free survival time was 13.07 months and 23.54 months in low- and high- miR-34a group, respectively (*P < 0.05)

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