Table 5 Upstream regulators of metronomic CPA-responsive mouse genes
Upstream regulator | Molecule type | p-value of overlap | # of target genes |
|---|---|---|---|
A. Activated upstream regulators (mouse gene targets) | |||
IFNAR | Interferon receptor | 5.34E-14 | 31 |
IRF3 | Transcription regulator | 5.62E-12 | 28 |
IFNG | Interferon | 2.55E-11 | 80 |
IL12 (complex) | Cytokine | 1.04E-10 | 24 |
STAT1 | Transcription regulator | 1.32E-10 | 37 |
IRF7 | Transcription regulator | 1.64E-10 | 23 |
IFN alpha/beta | Interferon | 3.98E-09 | 20 |
NFATC2 | Transcription regulator | 4.77E-09 | 26 |
IFNB1 | Cytokine | 9.37E-09 | 34 |
TLR4 | Toll-like receptor | 3.19E-08 | 42 |
DOCK8 | other | 4.22E-08 | 21 |
SASH1 | other | 7.34E-08 | 21 |
TICAM1 | Adapter for TLR3 | 1.05E-07 | 28 |
ITK | Kinase | 1.52E-07 | 22 |
SAMSN1 | other | 2.20E-07 | 23 |
mir-223 | MicroRNA | 3.67E-07 | 24 |
DDX58 | Enzyme | 1.15E-06 | 14 |
IL6 | Interleukin 6 | 1.22E-06 | 30 |
SPI1 | Transcription regulator | 1.31E-06 | 19 |
IKBKB | Kinase that activates REL/NF B | 3.41E-06 | 31 |
NOS2 | Nitric oxide synthase; M1 macrophage marker | 3.83E-06 | 30 |
MYD88 | Adapter for TLRs | 7.34E-06 | 32 |
TLR3 | Transmembrane receptor | 8.10E-06 | 27 |
BNIP3L | Pro-apoptotic factor | 9.69E-06 | 15 |
TLR9 | Transmembrane receptor | 1.33E-05 | 25 |
NLRP3 | Inflammasome | 1.59E-05 | 15 |
IRF5 | Transcription regulator | 2.22E-05 | 12 |
PPARG | Ligand-dependent nuclear receptor | 5.21E-05 | 40 |
IL18 | Cytokine | 6.86E-05 | 11 |
FADD | Transmembrane receptor adapter protein | 7.33E-05 | 15 |
CD44 | Enzyme | 7.53E-05 | 22 |
CDKN2A | Transcription regulator | 8.10E-05 | 20 |
B. Inhibited upstream regulators (mouse gene targets) | |||
CSF2/GM-CSF | Cytokine | 3.82E-15 | 45 |
TRIM24 | Transcription regulator | 8.10E-13 | 32 |
PTGER2 | G-protein coupled receptor | 1.65E-09 | 26 |
DNASE2 | Enzyme | 4.26E-08 | 14 |
ACKR2 | G-protein coupled receptor | 4.87E-08 | 15 |
SOCS1 | other | 1.26E-07 | 20 |
mir-21 | MicroRNA | 1.67E-06 | 25 |
TGFB1 | Growth factor | 9.61E-06 | 19 |
MYC | Transcription regulator | 1.46E-05 | 24 |