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Table 4 Enriched clusters of gene annotation terms for host (mouse) genes up-regulated (A) or-down-regulated (B) by metronomic CPA treatment in both U251 and 9L tumors

From: Transcriptional profiling provides insights into metronomic cyclophosphamide-activated, innate immune-dependent regression of brain tumor xenografts

Cluster name

Cluster enrichment score

Number of genes (top term)

p-value (top term)

A. Up-regulated mouse gene clusters

Glycoprotein

23.1

342

5.16E-37

Immune response

13.7

87

1.11E-26

Cell surface

8.80

53

8.91E-14

Lysosome

7.38

31

2.29E-08

Extracellular membrane

6.77

191

4.07E-12

Regulation of cytokine production

6.44

28

9.78E-10

Carbohydrate binding

5.64

41

5.09E-08

Positive regulation of immune system process

4.69

41

8.70E-14

Cytokine-cytokine receptor interaction

4.10

36

1.79E-07

Lipid catabolic process

3.60

23

7.60E-07

Induction of programmed cell death

3.24

24

9.43E-06

Cell/leukocyte activation

3.22

35

6.63E-08

B. Down-regulated mouse gene clusters

(Positive) regulation of transcription

10.3

71

1.06E-13

Cell division

9.31

44

4.73E-13

Repressor, negative regulation of gene expression

5.57

43

5.73E-08

Cell migration

4.81

28

6.05E-06

Spindle

4.58

20

1.22E-07

Skeletal system development

4.30

32

2.56E-06

Tube development

4.09

29

1.27E-05

Transcription factor complex

3.80

27

5.88E-06

Microtubule cytoskeleton organization

3.46

16

9.14E-05

Sequence-specific DNA binding/Homeodomain

3.04

52

4.54E-07

  1. Analysis was based on genes that respond to metronomic CPA treatment cycles at |fold-change| >1.5 and p-value < 104 at either, or both U251 treatment time points, and also in 9L tumors. Shown are clusters with enrichment scores >3.0 whose top term contains >15 genes. Also shown is the number of genes and p-value for the top term in each cluster. See Additional files 1: Table S5A and S5B for a more complete listing of significant enrichment clusters and associated gene lists.