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Table 1 Significant fold changes of expression of genes involved in cell proliferation, cell cycle regulation and DNA replication by knockdown of WT1 or p63 in FaDu cells

From: Wilms’ tumor gene 1 regulates p63 and promotes cell proliferation in squamous cell carcinoma of the head and neck

Term Gene name Expected effect* Fold change (vs control)
    siWT1 RNA sip63 RNA
Cell proliferation MMP7 Activator 2.11 4.11
  NGFR Activator 0.47 0.36
  IL8 Activator 0.46 2.22
  IGFBP3 Suppressor 2.63 2.85
  RARRES1 Suppressor 2.48 8.36
  TIMP2 Suppressor 2.12 2.07
  CDKN1B Suppressor 2.09 2.45
  LDOC1 Suppressor 2.01 2.69
  TOB2 Suppressor 0.48 0.36
  SFN Suppressor 0.41 0.38
Cell cycle TGM2 Activator 4.14 4.22
  Skp2 Activator 0.49 0.46
  C13orf15 Activator/Suppressor 4.07 15.17
  SMAD6 Unspecified 3.19 3.06
  CITED2 Unspecified 2.30 3.18
DNA replication MCM3 Activator 0.48 0.49
  MCM5 Activator 0.40 0.48
  RFC3 Activator 0.37 0.44
  1. *Expected effect of the listed genes was based on previous studies.
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BMC Cancer

ISSN: 1471-2407

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