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Table 1 Significant fold changes of expression of genes involved in cell proliferation, cell cycle regulation and DNA replication by knockdown of WT1 or p63 in FaDu cells

From: Wilms’ tumor gene 1 regulates p63 and promotes cell proliferation in squamous cell carcinoma of the head and neck

Term

Gene name

Expected effect*

Fold change (vs control)

   

siWT1 RNA

sip63 RNA

Cell proliferation

MMP7

Activator

2.11

4.11

 

NGFR

Activator

0.47

0.36

 

IL8

Activator

0.46

2.22

 

IGFBP3

Suppressor

2.63

2.85

 

RARRES1

Suppressor

2.48

8.36

 

TIMP2

Suppressor

2.12

2.07

 

CDKN1B

Suppressor

2.09

2.45

 

LDOC1

Suppressor

2.01

2.69

 

TOB2

Suppressor

0.48

0.36

 

SFN

Suppressor

0.41

0.38

Cell cycle

TGM2

Activator

4.14

4.22

 

Skp2

Activator

0.49

0.46

 

C13orf15

Activator/Suppressor

4.07

15.17

 

SMAD6

Unspecified

3.19

3.06

 

CITED2

Unspecified

2.30

3.18

DNA replication

MCM3

Activator

0.48

0.49

 

MCM5

Activator

0.40

0.48

 

RFC3

Activator

0.37

0.44

  1. *Expected effect of the listed genes was based on previous studies.