WT1 regulates p63 transcription through multiple genes with microarray analysis. A. Venn diagram of the number of differentially expressed genes with a fold change greater than two and a p value less than 0.05 following WT1 or p63 gene knockdown in FaDu cells. WT1 and p63 regulated genes displayed an overlap of 124 genes. B. Altered gene expression of known WT1 and p63 target genes by WT1 siRNA transfection in FaDu cells. Network analysis was performed based on array data using GeneGo software. Increased gene expression is indicated by a red circle on the upper right corner of each network object, whereas a blue dot indicates downregulation. Different shapes and colors represent various gene/protein function.