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Table 2 Univariate and multivariate cox regression analyses of prognostic factors in nasopharyngeal carcinoma

From: High expression of Talin-1 is associated with poor prognosis in patients with nasopharyngeal carcinoma

  Univariate analysis Multivariate analysis
Variable HR 95% CI P-value* HR 95% CI P-value*
Overall survival
Talin-1 expression (high vs. low) 2.15 1.28-3.63 0.004 1.87 1.10-3.16 0.02
TNM stage (III-IV vs. I-II) 3.06 1.45-6.47 0.003 2.97 1.40-6.29 0.005
Age (≥45 years vs. <45 years) 1.63 0.96-2.78 0.07    
Sex (male vs. female) 1.57 0.83-2.96 0.17    
WHO Type (III vs. I-II) 0.63 0.20-2.03 0.44    
VCA-IgA (≥1:80 vs. < 1:80) 1.50 0.64-3.49 0.35    
EA-IgA (≥1:10 vs. < 1:10) 1.04 0.56-1.93 0.90    
Distant metastasis-free survival
Talin-1 expression (high vs. low) 2.39 1.38-4.15 0.002 2.18 1.25-3.78 0.006
TNM stage (III-IV vs. I-II) 3.78 1.61-8.86 0.002 3.48 1.48-8.17 0.004
Age (≥45 years vs. < 45 years) 1.58 0.90-2.78 0.11    
Sex (male vs. female) 1.51 0.77-2.94 0.23    
WHO Type (III vs. I-II) 0.54 0.17-1.73 0.30    
VCA-IgA (≥1:80 vs. < 1:80) 1.10 0.50-2.45 0.81    
EA-IgA (≥1:10 vs. < 1:10) 1.30 0.65-2.60 0.45    
  1. Abbreviations: WHO: World Health Organization; VCA-IgA: viral capsid antigen immunoglobulin A; EA-IgA: early antigen immunoglobulin A. P-values* were calculated using univariate and multivariate cox regression analyses.