Table 2 Distributions of clinicopathologic characteristics by KRAS codon 12 and codon 13 mutation

Sex

0.005

0.12

 Male

107 (52.2%)

301 (63.6%)

32 (53.3%)

 Female

98 (47.8%)

172 (36.4%)

28 (46.7%)

Tumor location

<0.0001

<0.0001

 Proximal colon

58 (29.1%)

76 (16.7%)

15 (25.0%)

 Distal colon

40 (20.1%)

253 (55.7%)

13 (21.7%)

 Rectum

101 (50.8%)

125 (27.6%)

32 (53.3%)

pT stage

0.20

0.89

 pT1-2

22 (10.7%)

68 (14.4%)

9 (15.0%)

 pT3-4

183 (89.3%)

405 (85.6%)

51 (85.0%)

pN stage

0.02

0.90

 pN0

91 (44.4%)

256 (54.1%)

33 (55.0%)

 pN1-2

114 (55.6%)

217 (45.9%)

27 (45.0%)

Disease stage

0.03

0.99

 I-II

90 (43.9%)

252 (53.3%)

32 (53.3%)

 III-IV

115 (56.1%)

221 (46.7%)

28 (46.7%)

Tumor grade

0.14

0.26^‡

 G1-2

176 (85.9%)

384 (81.2%)

45 (75.0%)

 G3

29 (14.1%)

89 (18.8%)

15 (25.0%)

Histological type

0.001

0.007

 Mucinous

69 (33.7%)

100 (21.1%)

22 (36.7%)

 Ohter

136 (66.3%)

373 (78.9%)

38 (63.3%)

MMR status

0.87

0.30^‡

 Proficient

190 (92.7%)

440 (93.0%)

53 (88.3%)

 Deficient

15 (7.3%)

33 (7.0%)

7 (11.7%)

Age, y

0.59^†

0.47^†

 Mean (SD)

57.6 ± 11.4

57.1 ± 11.5

58.3 ± 10.6

 Median

59.0

58.0

57.5

 Range

27.0-84.0

21.0-87.0

31.0-77.0

Age,y

0.86

0.09

 <45

31 (15.1%)

69 (14.6%)

4 (6.7%)

 ≥45

174 (84.9%)

404 (85.4%)

56 (93.3%)

Tumor size (cm)

0.27

0.96

 Mean (SD)

4.99 ± 2.13

4.82 ± 1.76

4.83 ± 1.92

 Median

4.5

4.5

4.4

 Range

1.5-17.0

1.0-14.0

3.5-12.0

Tumor size

0.77

0.28

 <4.5 cm

90 (43.9%)

202 (42.7%)

30 (50.0%)

 ≥4.5 cm

115 (56.1%)

271 (57.3%)

30 (50.0%)