From: Colorectal carcinomas with KRAS codon 12 mutation are associated with more advanced tumor stages
Characterics | MutantKRAS | Wild-typeKRAS | P-value | MutantBRAF | Wild-typeBRAF | P-value |
---|---|---|---|---|---|---|
(n = 265) | (n = 496) | (n = 23) | (n = 738) | |||
Sex | Â | Â | 0.005 | Â | Â | 0.26 |
 Male | 139 (52.5%) | 312 (62.9%) |  | 11 (47.8%) | 440 (59.6%) |  |
 Female | 126 (47.5%) | 184 (37.1%) |  | 12 (52.2%) | 298 (40.4%) |  |
Tumor location | Â | Â | 0.004 | Â | Â | <0.0001 |
 Proximal colon | 73 (28.3%) | 90 (18.7%) |  | 14 (60.9%) | 149 (20.9%) |  |
 Distal colon | 52 (20.2%) | 135 (28.0%) |  | 5 (21.7%) | 178 (25.0%) |  |
 Rectum | 133 (51.5%) | 257 (53.3%) |  | 4 (17.4%) | 386 (54.1%) |  |
pT stage |  |  | 0.39 |  |  | 0.35‡ |
 pT1-2 | 31 (11.7%) | 69 (13.9%) |  | 1 (4.3%) | 98 (13.3%) |  |
 pT3-4 | 234 (88.3%) | 427 (86.1%) |  | 22 (95.7%) | 640 (86.7%) |  |
pN stage | Â | Â | 0.09 | Â | Â | 0.11 |
 pN0 | 124 (46.8%) | 264 (53.2%) |  | 8 (34.8%) | 380 (51.5%) |  |
 pN1-2 | 141 (53.2%) | 232 (46.8%) |  | 15 (65.2%) | 358 (48.5%) |  |
Disease stage | Â | Â | 0.10 | Â | Â | 0.13 |
 I-II | 123 (46.2%) | 260 (52.4%) |  | 8 (34.8%) | 374 (50.7%) |  |
 III-IV | 143 (53.8%) | 236 (47.6%) |  | 15 (65.2%) | 364 (49.3%) |  |
Tumor grade |  |  | 0.26 |  |  | 0.005‡ |
 G1-2 | 221 (83.4%) | 397 (80.0%) |  | 13 (56.5%) | 605 (82.0%) |  |
 G3 | 44 (16.6%) | 99 (20.0%) |  | 10 (43.5%) | 133 (18.0%) |  |
Histological type |  |  | 0.004 |  |  | <0.0001‡ |
 Mucinous | 92 (34.7%) | 123 (24.8%) |  | 16 (69.6%) | 191 (25.9%) |  |
 Ohter | 173 (65.3%) | 373 (75.2%) |  | 7 (30.4%) | 547 (74.1%) |  |
MMR status |  |  | 0.76 |  |  | 0.03§ |
 Proficient | 243 (91.7%) | 458 (92.3%) |  | 18 (78.3%) | 682 (92.4%) |  |
 Deficient | 22 (8.3%) | 38 (7.7%) |  | 5 (21.7%) | 56 (7.6%) |  |
Age, y |  |  | 0.65†|  |  | 0.35†|
 Mean (SD) | 57.7 ± 11.3 | 57.3 ± 11.5 |  | 59.6 ± 10.1 | 57.3 ± 11.4 |  |
 Median | 58.5 | 58.0 |  | 59.0 | 58.0 |  |
 Range | 27.0-84.0 | 21.0-87.0 |  | 38.0-82.0 | 21.0-87.0 |  |
Age,y |  |  | 0.95 |  |  | 0.23‡ |
 <45 | 37 (14.0%) | 70 (14.1%) |  | 1 (4.3%) | 105 (14.2%) |  |
 ≥45 | 228 (86.0%) | 426 (85.9%) |  | 22 (95.7%) | 633 (85.8%) |  |
Tumor size (cm) |  |  | 0.68†|  |  | 0.004†|
 Mean (SD) | 4.95 ± 2.08 | 4.89 ± 1.81 |  | 5.83 ± 2.13 | 4.87 ± 1.89 |  |
 Median | 4.5 | 4.5 |  | 6 | 4.5 |  |
 Range | 1.5-17.0 | 1.0-14.0 |  | 3.0-11.0 | 1.0-17.0 |  |
Tumor size | Â | Â | 0.32 | Â | Â | 0.09 |
 <4.5 cm | 121 (45.7%) | 208 (41.9%) |  | 6 (26.1%) | 322 (43.6%) |  |
 ≥4.5 cm | 144 (54.3%) | 288 (58.1%) |  | 17 (73.9%) | 416 (56.4%) |  |