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Table 1 Distributions of clinicopathologic characteristics by KRAS and BRAF mutation status

From: Colorectal carcinomas with KRAS codon 12 mutation are associated with more advanced tumor stages

Characterics

MutantKRAS

Wild-typeKRAS

P-value

MutantBRAF

Wild-typeBRAF

P-value

(n = 265)

(n = 496)

(n = 23)

(n = 738)

Sex

  

0.005

  

0.26

 Male

139 (52.5%)

312 (62.9%)

 

11 (47.8%)

440 (59.6%)

 

 Female

126 (47.5%)

184 (37.1%)

 

12 (52.2%)

298 (40.4%)

 

Tumor location

  

0.004

  

<0.0001

 Proximal colon

73 (28.3%)

90 (18.7%)

 

14 (60.9%)

149 (20.9%)

 

 Distal colon

52 (20.2%)

135 (28.0%)

 

5 (21.7%)

178 (25.0%)

 

 Rectum

133 (51.5%)

257 (53.3%)

 

4 (17.4%)

386 (54.1%)

 

pT stage

  

0.39

  

0.35‡

 pT1-2

31 (11.7%)

69 (13.9%)

 

1 (4.3%)

98 (13.3%)

 

 pT3-4

234 (88.3%)

427 (86.1%)

 

22 (95.7%)

640 (86.7%)

 

pN stage

  

0.09

  

0.11

 pN0

124 (46.8%)

264 (53.2%)

 

8 (34.8%)

380 (51.5%)

 

 pN1-2

141 (53.2%)

232 (46.8%)

 

15 (65.2%)

358 (48.5%)

 

Disease stage

  

0.10

  

0.13

 I-II

123 (46.2%)

260 (52.4%)

 

8 (34.8%)

374 (50.7%)

 

 III-IV

143 (53.8%)

236 (47.6%)

 

15 (65.2%)

364 (49.3%)

 

Tumor grade

  

0.26

  

0.005‡

 G1-2

221 (83.4%)

397 (80.0%)

 

13 (56.5%)

605 (82.0%)

 

 G3

44 (16.6%)

99 (20.0%)

 

10 (43.5%)

133 (18.0%)

 

Histological type

  

0.004

  

<0.0001‡

 Mucinous

92 (34.7%)

123 (24.8%)

 

16 (69.6%)

191 (25.9%)

 

 Ohter

173 (65.3%)

373 (75.2%)

 

7 (30.4%)

547 (74.1%)

 

MMR status

  

0.76

  

0.03§

 Proficient

243 (91.7%)

458 (92.3%)

 

18 (78.3%)

682 (92.4%)

 

 Deficient

22 (8.3%)

38 (7.7%)

 

5 (21.7%)

56 (7.6%)

 

Age, y

  

0.65†

  

0.35†

 Mean (SD)

57.7 ± 11.3

57.3 ± 11.5

 

59.6 ± 10.1

57.3 ± 11.4

 

 Median

58.5

58.0

 

59.0

58.0

 

 Range

27.0-84.0

21.0-87.0

 

38.0-82.0

21.0-87.0

 

Age,y

  

0.95

  

0.23‡

 <45

37 (14.0%)

70 (14.1%)

 

1 (4.3%)

105 (14.2%)

 

 ≥45

228 (86.0%)

426 (85.9%)

 

22 (95.7%)

633 (85.8%)

 

Tumor size (cm)

  

0.68†

  

0.004†

 Mean (SD)

4.95 ± 2.08

4.89 ± 1.81

 

5.83 ± 2.13

4.87 ± 1.89

 

 Median

4.5

4.5

 

6

4.5

 

 Range

1.5-17.0

1.0-14.0

 

3.0-11.0

1.0-17.0

 

Tumor size

  

0.32

  

0.09

 <4.5 cm

121 (45.7%)

208 (41.9%)

 

6 (26.1%)

322 (43.6%)

 

 ≥4.5 cm

144 (54.3%)

288 (58.1%)

 

17 (73.9%)

416 (56.4%)

 
  1. Abbreviations: MMR mismatch repair, SD standard deviation.
  2. †Two-sided Kruskal Wallis test.
  3. ‡Two-sided χ2 test with continuity correction.
  4. §Fischer’s exact test.
  5. Others are two-sided χ2 test.