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Table 3 Estimated pharmacokinetic parameters of 5-FU in rats after 5-FU administration (100 mg/kg, i.v.)

From: Local pelvic irradiation modulates Pharmacokinetics of 5-Fluorouracil in the plasma but not in the Lymphatic System

Parameters

Plasma

Lymphatic fluid

 

Without RT

With RT

Without RT

With RT

AUC (min μg/mL)

4353 ± 257

3108 ± 114*

14240 ± 734

15251 ± 1195

T1/2 (min)

28 ± 0.93

26.6 ± 1.67

30.0 ± 6.49

24.4 ± 1.98

Cmax (μg/mL)

119 ± 11.3

102 ± 8.4

153 ± 6.2

163 ± 9.45

CL (mL/min/kg)

23.1 ± 1.41

32.2 ± 1.25*

7.1 ± 0.37

6.73 ± 0.46

MRT (min)

34 ± 1.37

25.9 ± 1.97*

26.3 ± 1.97

27.6 ± 2.38

Vss (mL/kg)

834 ± 63.4

863 ± 50.3

192 ± 20.7

191 ± 26.1

  1. Data expressed as mean ± SEM (n = 6). AUC, area under the concentration versus time curve; T1/2, elimination half-life; Cmax, the peak plasma concentration of a drug after administration; CL, total body clearance; MRT, mean residence time; Vss, volume of distribution. *significantly different from without RT group at p < 0.05.
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BMC Cancer

ISSN: 1471-2407

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