Skip to main content

Table 3 Estimated pharmacokinetic parameters of 5-FU in rats after 5-FU administration (100 mg/kg, i.v.)

From: Local pelvic irradiation modulates Pharmacokinetics of 5-Fluorouracil in the plasma but not in the Lymphatic System

Parameters Plasma Lymphatic fluid
  Without RT With RT Without RT With RT
AUC (min μg/mL) 4353 ± 257 3108 ± 114* 14240 ± 734 15251 ± 1195
T1/2 (min) 28 ± 0.93 26.6 ± 1.67 30.0 ± 6.49 24.4 ± 1.98
Cmax (μg/mL) 119 ± 11.3 102 ± 8.4 153 ± 6.2 163 ± 9.45
CL (mL/min/kg) 23.1 ± 1.41 32.2 ± 1.25* 7.1 ± 0.37 6.73 ± 0.46
MRT (min) 34 ± 1.37 25.9 ± 1.97* 26.3 ± 1.97 27.6 ± 2.38
Vss (mL/kg) 834 ± 63.4 863 ± 50.3 192 ± 20.7 191 ± 26.1
  1. Data expressed as mean ± SEM (n = 6). AUC, area under the concentration versus time curve; T1/2, elimination half-life; Cmax, the peak plasma concentration of a drug after administration; CL, total body clearance; MRT, mean residence time; Vss, volume of distribution. *significantly different from without RT group at p < 0.05.
\