Local pelvic irradiation modulates Pharmacokinetics of 5-Fluorouracil in the plasma but not in the Lymphatic System

Table 1 Recovery of 5-FU in rat plasma and lymphatic fluid

Matrices	Nominal concentration (μg/mL)	Set 1 Peak area	Set 2 Peak area	Recovery (%)
Plasma	1	66301 ± 412	39467 ± 1211	59.53 ± 1.83
	10	632542 ± 4183	355741 ± 14191	56.24 ± 2.24
	100	6463129 ± 22755	3631833 ± 429923	56.19 ± 6.65
	Mean ± SD			57.32 ± 4.25
Lymphatic fluid	1	66301 ± 412	38174 ± 1136	57.58 ± 1.71
	10	632542 ± 4183	336695 ± 32677	53.23 ± 5.17
	100	6463129 ± 22755	3689380 ± 141268	57.08 ± 2.19
	Mean ± SD			55.96 ± 3.76

Data expressed as mean ± SD (n = 6). Recovery calculated as the ratio of the mean peak area of an analyte spiked before extraction (set 2) to the mean peak area of an analyte spiked in the neat mobile phase (set 1) multiplied by 100.

ISSN: 1471-2407