Table 6 Comparison of ontological categories differentially expressed in Cetuximab-sensitive vs . resistant cell lines
| Â | Cetuximab: Overexpressed in sensitive cells | Â | Â | Overexpressed in resistant cells | Â |
|---|---|---|---|---|---|
| Â | Term | p_value | Â | Term | p_value |
Table 6a | |||||
IM | response to wounding | 1.3E-10 | DF | ectoderm development | 9.2E-10 |
CC | regulation of cell proliferation | 1.6E-09 | DF | epidermis development | 1.4E-09 |
CC | positive regulation of cell proliferation | 3.5E-07 | DF | epithelium development | 1.0E-08 |
M | chemotaxis | 8.9E-07 | DF | epithelial cell differentiation | 1.5E-07 |
M | taxis | 8.9E-07 | DF | keratinocyte differentiation | 6.2E-05 |
M | cell migration | 1.7E-06 | DF | cornified envelope | 6.5E-05 |
M | localization of cell | 2.6E-06 | EC | extracellular matrix | 7.8E-05 |
M | cell motility | 2.6E-06 | DF | epidermal cell differentiation | 1.2E-04 |
M | Cell communication | 3.5E-06 | DF | peptide cross-linking | 1.7E-04 |
R | regulation of response to external stimulus | 4.0E-06 | IM | wound healing | 1.7E-04 |
Table 6b | |||||
IM | inflammatory response | 6.5E-06 | CC | regulation of cell proliferation | 4.3E-04 |
IM | wound healing | 9.1E-06 | CY | Cell structure and motility | 3.3E-04 |
IM | immune response | 9.8E-06 | CY | 12q12-q13 | 6.9E-04 |
IM | Immunity and defense | 6.7E-05 | T | transcription repressor activity | 8.4E-04 |
IM | regulation of inflammatory response | 3.5E-04 | Â | Â | Â |
S | Signal transduction | 1.5E-05 | Â | Â | Â |
S | Jak-STAT signaling pathway | 5.1E-04 | Â | Â | Â |
S | JAK-STAT cascade | 6.7E-04 | Â | Â | Â |
V | regulation of vascular endothelial growth factor production | 3.2E-05 | Â | Â | Â |
V | Angiogenesis | 3.8E-05 | Â | Â | Â |
V | blood coagulation | 5.8E-04 | Â | Â | Â |