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Table 5 Comparison of ontological categories differentially expressed in irreversible inhibitor-sensitive vs . resistant cell lines

From: Transcriptional changes associated with resistance to inhibitors of epidermal growth factor receptor revealed using metaanalysis

  Irreversible: Overexpression in sensitive cells   Overexpression in resistant cells
  Term p_value   Term p_value
Table 5a
MM endomembrane system 3.8E-09 EC extracellular region 1.6E-08
MM Golgi apparatus 2.4E-07   ectoderm development 3.3E-07
MM cell fraction 1.0E-05 IM response to wounding 4.3E-07
CC cell division 2.1E-05 EC extracellular region part 1.3E-06
MM organelle membrane 3.1E-05 EC extracellular space 2.4E-06
MM nuclear envelope-endoplasmic reticulum network 5.9E-05   epidermis development 8.4E-06
R response to organic substance 8.1E-05 CC regulation of cell proliferation 1.1E-05
MM endoplasmic reticulum membrane 1.0E-04 CC regulation of smooth muscle cell proliferation 6.5E-05
CC Mitosis 1.1E-04 IM wound healing 7.3E-05
MM 1p22.1 1.5E-04 CC positive regulation of smooth muscle cell proliferation 1.9E-04
Table 5b
CC cell cycle 3.1E-04 IM defense response 5.9E-04
M_l steroid metabolic process 4.3E-04 IM inflammatory response 9.2E-04
    O epidermal growth factor receptor binding 2.5E-04
    O ErbB signaling pathway 4.2E-04
Genes overexpressed in resistant cells
Table 5c  
EGFR Binding ligands ErbB sig pathway
amphiregulin; amphiregulin B Cas-Br-M ecotropic retroviral transforming sequence c
epidermal growth factor receptor amphiregulin; amphiregulin B
Epiregulin epidermal growth factor receptor
heparin-binding EGF-like growth factor epiregulin
  heparin-binding EGF-like growth factor
  transforming growth factor, alpha
  v-erb-b2 oncogene homolog 3
  1. a) Top ten categories with best p-values. b) Selected categories with p-value better than 10-4 (see Additional file 6). c) Genes expressed in EGFR binding and ErbB signaling pathway ontologies in resistant cell lines.