Table 4 Comparison of ontological categories differentially expressed in Gefitinib-sensitive vs . resistant cell lines
| Â | Gefitinib: Overexpressed in sensitive cells | Â | Â | Overexpressed in resistant cells | Â |
|---|---|---|---|---|---|
| Â | Term | p_value | Â | Term | p_value |
Table 4a | |||||
O | Pathways in cancer | 6.8E-14 | T | positive regulation of biosynthetic process | 1.7E-11 |
O | Pancreatic cancer | 1.2E-07 | T | positive regulation of macromolecule metabolic process | 3.1E-11 |
T | protein complex assembly | 3.7E-06 | T | positive regulation of cellular biosynthetic process | 3.5E-11 |
T | protein complex biogenesis | 3.7E-06 | T | positive regulation of nitrogen compound metabolic process | 1.6E-10 |
CC | regulation of cell proliferation | 3.9E-06 | T | positive regulation of macromolecule biosynthetic process | 4.4E-10 |
O | Bladder cancer | 7.8E-06 | R | response to endogenous stimulus | 5.1E-10 |
S | regulation of protein kinase cascade | 8.7E-06 | CC | positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 3.6E-09 |
AD | cell adhesion | 9.0E-06 | R | response to hormone stimulus | 8.1E-09 |
AD | biological adhesion | 9.8E-06 | O | Pathways in cancer | 1.0E-08 |
T | positive regulation of macromolecule metabolic process | 1.0E-05 | T | positive regulation of transcription | 1.5E-08 |
Table 4b | |||||
A | regulation of cell death | 3.6E-05 | A | negative regulation of programmed cell death | 1.0E-06 |
A | negative regulation of cell death | 4.4E-05 | CC | regulation of cell proliferation | 3.5E-08 |
A | regulation of apoptosis | 7.9E-05 | CC | positive regulation of cell proliferation | 1.9E-06 |
CC | cell proliferation | 1.6E-05 | CC | cell cycle | 2.7E-04 |
M_l | regulation of lipid metabolic process | 3.1E-05 | CY | cytoskeleton organization | 5.3E-06 |
M_l | positive regulation of lipid metabolic process | 3.4E-04 | CY | cell morphogenesis | 2.0E-04 |
O | ErbB signaling pathway | 5.2E-04 | E | regulation of oxidoreductase activity | 4.9E-04 |
| Â | Â | Â | HY | response to hypoxia | 8.7E-06 |
| Â | Â | HY | response to reactive oxygen species | 2.4E-04 | |
| Â | Â | Â | HY | response to hydrogen peroxide | 6.3E-04 |
| Â | Â | Â | IM | immune system development | 4.1E-07 |
| Â | Â | Â | IM | regulation of cytokine production | 9.2E-07 |
| Â | Â | Â | IM | regulation of cytokine biosynthetic process | 2.8E-06 |
| Â | Â | Â | IM | response to wounding | 7.3E-05 |
| Â | Â | Â | IM | positive regulation of cytokine biosynthetic process | 1.1E-04 |
| Â | Â | Â | IM | Signaling in Immune system | 1.3E-04 |
| Â | Â | Â | M_c | glucose metabolic process | 5.1E-04 |
| Â | Â | Â | M_l | regulation of lipid metabolic process | 2.9E-04 |
| Â | Â | Â | R | response to steroid hormone stimulus | 4.5E-08 |
| Â | Â | Â | R | response to nutrient levels | 3.6E-07 |
| Â | Â | Â | R | response to extracellular stimulus | 6.8E-07 |
| Â | Â | Â | R | response to drug | 2.5E-06 |
| Â | Â | Â | R | response to nutrient | 3.7E-05 |
| Â | Â | Â | R | response to vitamin | 3.7E-05 |
| Â | Â | Â | R | response to corticosteroid stimulus | 4.3E-05 |
| Â | Â | Â | R | response to glucocorticoid stimulus | 9.1E-05 |
| Â | Â | Â | R | response to lipopolysaccharide | 1.7E-04 |
| Â | Â | Â | R | response to abiotic stimulus | 3.4E-04 |
| Â | Â | Â | R | negative regulation of response to external stimulus | 6.8E-04 |
| Â | Â | Â | V | hemopoiesis | 1.2E-07 |
| Â | Â | Â | V | leukocyte differentiation | 9.4E-06 |
| Â | Â | Â | V | blood circulation | 4.9E-05 |
| Â | Â | Â | V | circulatory system process | 4.9E-05 |
| Â | Â | Â | V | lymphocyte differentiation | 7.4E-05 |
| Â | Â | Â | V | regulation of angiogenesis | 1.1E-04 |
| Â | Â | Â | V | blood vessel development | 1.2E-04 |
| Â | Â | Â | V | vasculature development | 1.8E-04 |