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Table 4 Comparison of ontological categories differentially expressed in Gefitinib-sensitive vs . resistant cell lines

From: Transcriptional changes associated with resistance to inhibitors of epidermal growth factor receptor revealed using metaanalysis

  Gefitinib: Overexpressed in sensitive cells    Overexpressed in resistant cells  
  Term p_value   Term p_value
Table 4a
O Pathways in cancer 6.8E-14 T positive regulation of biosynthetic process 1.7E-11
O Pancreatic cancer 1.2E-07 T positive regulation of macromolecule metabolic process 3.1E-11
T protein complex assembly 3.7E-06 T positive regulation of cellular biosynthetic process 3.5E-11
T protein complex biogenesis 3.7E-06 T positive regulation of nitrogen compound metabolic process 1.6E-10
CC regulation of cell proliferation 3.9E-06 T positive regulation of macromolecule biosynthetic process 4.4E-10
O Bladder cancer 7.8E-06 R response to endogenous stimulus 5.1E-10
S regulation of protein kinase cascade 8.7E-06 CC positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3.6E-09
AD cell adhesion 9.0E-06 R response to hormone stimulus 8.1E-09
AD biological adhesion 9.8E-06 O Pathways in cancer 1.0E-08
T positive regulation of macromolecule metabolic process 1.0E-05 T positive regulation of transcription 1.5E-08
Table 4b
A regulation of cell death 3.6E-05 A negative regulation of programmed cell death 1.0E-06
A negative regulation of cell death 4.4E-05 CC regulation of cell proliferation 3.5E-08
A regulation of apoptosis 7.9E-05 CC positive regulation of cell proliferation 1.9E-06
CC cell proliferation 1.6E-05 CC cell cycle 2.7E-04
M_l regulation of lipid metabolic process 3.1E-05 CY cytoskeleton organization 5.3E-06
M_l positive regulation of lipid metabolic process 3.4E-04 CY cell morphogenesis 2.0E-04
O ErbB signaling pathway 5.2E-04 E regulation of oxidoreductase activity 4.9E-04
    HY response to hypoxia 8.7E-06
   HY response to reactive oxygen species 2.4E-04
    HY response to hydrogen peroxide 6.3E-04
    IM immune system development 4.1E-07
    IM regulation of cytokine production 9.2E-07
    IM regulation of cytokine biosynthetic process 2.8E-06
    IM response to wounding 7.3E-05
    IM positive regulation of cytokine biosynthetic process 1.1E-04
    IM Signaling in Immune system 1.3E-04
    M_c glucose metabolic process 5.1E-04
    M_l regulation of lipid metabolic process 2.9E-04
    R response to steroid hormone stimulus 4.5E-08
    R response to nutrient levels 3.6E-07
    R response to extracellular stimulus 6.8E-07
    R response to drug 2.5E-06
    R response to nutrient 3.7E-05
    R response to vitamin 3.7E-05
    R response to corticosteroid stimulus 4.3E-05
    R response to glucocorticoid stimulus 9.1E-05
    R response to lipopolysaccharide 1.7E-04
    R response to abiotic stimulus 3.4E-04
    R negative regulation of response to external stimulus 6.8E-04
    V hemopoiesis 1.2E-07
    V leukocyte differentiation 9.4E-06
    V blood circulation 4.9E-05
    V circulatory system process 4.9E-05
    V lymphocyte differentiation 7.4E-05
    V regulation of angiogenesis 1.1E-04
    V blood vessel development 1.2E-04
    V vasculature development 1.8E-04
  1. a) Top ten categories with best p-values. b) Selected categories with p-value better than 10-4 (see Additional file 5).