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Table 3 Comparison of ontological categories differentially expressed in Erlotinib-sensitive vs. resistant cell lines, using DAVID program

From: Transcriptional changes associated with resistance to inhibitors of epidermal growth factor receptor revealed using metaanalysis

 

Erlotinib: Overexpressed in sensitive cells

  

Overexpressed in resistant cells

 
 

Term

p_value

 

Term

p_value

Table 3a

T

translation

5.6E-62

 

cytosol

3.0E-20

T

translational elongation

6.3E-45

T

translational elongation

3.1E-18

T

structural constituent of ribosome

1.0E-43

T

structural constituent of ribosome

3.4E-18

 

cytosol

3.7E-41

T

ribosomal subunit

3.5E-17

T

ribosome

4.5E-41

T

cytosolic ribosome

2.4E-16

T

3' -UTR-mediated translational regulation

3.8E-40

E

mitochondrion

1.5E-15

T

ribonucleoprotein complex

5.0E-40

T

Ribosome

2.6E-14

T

Ribosome

4.6E-37

T

ribosome

2.6E-14

T

ribosomal subunit

9.9E-36

IM

Influenza Infection

4.2E-14

T

Protein biosynthesis

2.0E-33

CY

intracellular non-membrane-bounded organelle

8.2E-13

Table 3b

CC

Cell cycle

1.8E-04

CC

mitotic cell cycle

3.2E-08

E

mitochondrion

2.4E-10

CC

M phase of mitotic cell cycle

9.1E-06

E

intramolecular oxidoreductase activity

4.4E-04

CY

actin cytoskeleton

5.3E-06

M_c

glycolysis

2.1E-07

E

mitochondrial inner membrane

7.1E-12

M_c

Metabolism of carbohydrates

3.3E-06

E

mitochondrial envelope

7.2E-12

M_c

carbohydrate catabolic process

7.5E-05

E

oxidative phosphorylation

1.5E-10

M_c

Glycolysis / Gluconeogenesis

1.7E-04

E

hydrogen ion transmembrane transporter activity

1.8E-10

M_c

glucose metabolic process

6.4E-04

E

generation of precursor metabolites and energy

3.4E-10

T

Metabolism of proteins

5.4E-29

E

Oxidoreductase

6.6E-10

T

ribosome biogenesis

6.6E-21

E

Dehydrogenase

3.9E-09

T

ncRNA metabolic process

4.7E-19

E

Integration of energy metabolism

1.6E-06

T

mitochondrial ribosome

4.0E-05

E

electron transport chain

1.8E-05

   

E

mitochondrial lumen

1.9E-04

   

E

mitochondrial matrix

1.9E-04

   

E

NADH dehydrogenase (ubiquinone) activity

2.3E-04

   

E

mitochondrial ATP synthesis coupled electron transport

2.8E-04

   

T

Metabolism of proteins

2.7E-09

   

T

Protein biosynthesis

1.6E-07

   

T

Gene Expression

1.5E-06

  1. a) Top ten categories with best p-values. b) Selected categories with p-value better than 10-4 (see Additional file 4).