Table 2 Patterns of the in situ distribution of PGs in HNSCC lesions (% of cases)
PG | Tumor cell positivity1 | Overall staining intensity2 | Subcellular localization3 | Stromal expression | ||||
|---|---|---|---|---|---|---|---|---|
GPC1 | - | (27.5) | - | (27.6) | Membrane | - | - | (92.0) |
+ | (29.2) | + | (33.1) | Cytoplasmic | - | + | (6.7) | |
++ | (33.1) | ++ | (30.1) | Both | (72.4) | ++ | (0.6) | |
+++ | (7.4) | +++ | (6.7) | +++ | (0.6) | |||
++++ | (2.5) | ++++ | (2.5) | ++++ | - | |||
GPC3 | - | (81.6) | - | (81.6) | Membrane | - | - | (100.0) |
+ | (14.1) | + | (14.1) | Cytoplasmic | - | + | - | |
++ | (3.1) | ++ | (4.3) | Both | (18.4) | ++ | - | |
+++ | (1.2) | +++ | - | +++ | - | |||
++++ | - | ++++ | - | ++++ | - | |||
GPC4 | - | (58.9) | - | (59.5) | Membrane | - | - | (81.0) |
+ | (20.9) | + | (14.1) | Cytoplasmic | (40.5) | + | (5.5) | |
++ | (19.0) | ++ | (25.8) | Both | - | ++ | (12.9) | |
+++ | (1.2) | +++ | (0.6) | +++ | (0.6) | |||
++++ | - | ++++ | - | ++++ | - | |||
GPC6 | - | (62.2) | - | (62.6) | Membrane | - | - | (90.2) |
+ | (30.1) | + | (31.9) | Cytoplasmic | (37.4) | + | (9.8) | |
++ | (7.4) | ++ | (5.5) | Both | - | ++ | - | |
+++ | - | +++ | - | +++ | - | |||
++++ | - | ++++ | - | ++++ | - | |||
SDC1 | - | (8.6) | - | (8.6) | Membrane | (42.9) | - | (79.1) |
+ | (31.3) | + | (25.8) | Cytoplasmic | (37.4) | + | (9.2) | |
++ | (33.7) | ++ | (50.3) | Both | (10.4) | ++ | (10.4) | |
+++ | (22.1) | +++ | (10.4) | +++ | (1.2) | |||
++++ | (4.3) | ++++ | (4.9) | ++++ | - | |||
SDC2 | - | (88.3) | - | (88.3) | Membrane | (1.8) | - | (26.4) |
+ | (6.7) | + | (8.0) | Cytoplasmic | (8.6) | + | (20.2) | |
++ | (4.3) | ++ | (3.1) | Both | - | ++ | (25.8) | |
+++ | (0.6) | +++ | (0.6) | +++ | (21.5) | |||
++++ | - | ++++ | - | ++++ | (6.1) | |||
SDC3 | - | (65.0) | - | (65.0) | Membrane | - | - | (100.0) |
+ | (27.0) | + | (28.2) | Cytoplasmic | - | + | - | |
++ | (6.1) | ++ | (6.7) | Both | (34.4) | ++ | - | |
+++ | (1.8) | +++ | - | +++ | - | |||
++++ | - | ++++ | - | ++++ | - | |||
SDC4 | - | (80.4) | - | (80.4) | Membrane | - | - | (100.0) |
+ | (16.0) | + | (19.6) | Cytoplasmic | - | + | - | |
++ | (3.7) | ++ | - | Both | (17.8) | ++ | - | |
+++ | - | +++ | - | +++ | - | |||
++++ | - | ++++ | - | ++++ | - | |||
NG2/CSPG4 | - | (34.2) | - | (34.2) | Membrane | (62.6) | - | (96.7) |
+ | (38.8) | + | (36.8) | Cytoplasmic | - | + | (3.3) | |
++ | (21.7) | ++ | (19.7) | Both | - | ++ | - | |
+++ | (2.6) | +++ | (7.2) | +++ | - | |||
++++ | (2.6) | ++++ | (2.0) | ++++ | - | |||