Table 5 Exploratory analysis on H-scores for stathmin, pS6, pMTOR and pAKT
Stathmin | |||
|---|---|---|---|
H-scores Range: 0-300/300; Optimal Cut-off*: 15/300 | |||
H-scores: High vs. Low | High H-scores (>15/300) | Low H-scores (≤15/300) |  |
Disease stabilization rate** | 7/21 (33%) | 7/13 (46%) | p = 0.238 |
OR for disease stabilization** | 0.429 (95% CI 0.104-1.770) | p = 0.242 | |
AFP response*** | 2/6 (33%) | 6/16 (38%) | p = 0.376 |
pS6 | |||
H-scores Range: 0-300/300; Optimal Cut-off*:120/300 | |||
H-scores: High vs. Low | High H-scores (>120/300) | Low H-scores (≤120/300) |  |
Disease stabilization rate** | 8/17 (47%) | 6/17 (35%) | p = 0.489 |
OR for disease stabilization** | 1.630 (95% CI 0.411-6.459) | p = 0.487 | |
AFP response*** | 4/11 (36%) | 4/11 (36%) | p = 0.341 |
pMTOR | |||
H-scores Range: 0-180/300; Optimal Cut-off*: 20/300 | |||
H-scores: High vs. Low | High H-scores (>20/300) | Low H-scores (≤20/300) |  |
Disease stabilization rate** | 7/10 (70%) | 7/24 (29%) | p = 0.028 |
OR for disease stabilization** | 5.667 (95% CI 1.129-28.454) | p = 0.035 | |
AFP response | 4/16 (25%) | 4/6 (67%) | p = 0.085 |
pAKT | |||
H-scores Range: 0-240/300; Optimal Cut-off*: 5/300 | |||
H-scores: High vs. Low | High H-scores (>5/300) | Low H-scores (≤5/300) |  |
Disease stabilization rate** | 4/11 (36%) | 10/23 (43%) | p = 0.693 |
OR for disease stabilization** | 0.743 (95% CI 0.169-3.262) | p = 0.694 | |
AFP response*** | 7/16 (44%) | 1/6 (17%) | p = 0.215 |