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Table 3 Haematological and non-haematological toxicities according to the NCI CTC (version 3.0) (n = 35)

From: Phase I/II study of temsirolimus for patients with unresectable Hepatocellular Carcinoma (HCC)- a correlative study to explore potential biomarkers for response

 

Worst grade (number of patients)

Toxicities

1-2

3

4

Mucositis- oral

26

1

0

Rash

20

0

0

Fatigue

17

1

0

Cough

15

1

0

Fever

14

0

0

Anorexia

13

0

0

Pulmonary-Other

13

0

0

Insomnia

12

0

0

Pain- head

12

0

0

Pain- abdomen

10

1

0

Haemorrhage, nose

10

0

0

Oedema- limb

10

0

0

Pruritus

10

0

0

Gastrointestinal-Other

9

0

0

Diarrhoea

8

3

0

Dysphagia

8

1

0

Nausea

8

0

0

Pain- others

8

0

0

Platelets

7

4

0

Dyspnoea

7

1

0

Constipation

7

0

0

Distension

7

0

0

Dry mouth

7

0

0

Haemorrhage, other

6

0

0

Rigors/chills

6

0

0

Vomiting

6

0

0

Hyperglycaemia

5

1

0

Dizziness

5

0

0

Dry skin

5

0

0

Musculoskeletal-Other

5

0

0

Pain- muscle

5

0

0

Taste alteration

5

0

0

Hypokalaemia

4

1

1

Hemorrhoids

4

1

0

Hyponatraemia

0

4

0

Ascites

4

0

0

Infection- others with normal neutrophil counts

4

0

0

Alanine transaminase

3

2

0

Hyperbilirubinaemia

1

2

1

Infection- upper airway with normal neutrophil counts

1

3

0