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Table 3 Haematological and non-haematological toxicities according to the NCI CTC (version 3.0) (n = 35)

From: Phase I/II study of temsirolimus for patients with unresectable Hepatocellular Carcinoma (HCC)- a correlative study to explore potential biomarkers for response

  Worst grade (number of patients)
Toxicities 1-2 3 4
Mucositis- oral 26 1 0
Rash 20 0 0
Fatigue 17 1 0
Cough 15 1 0
Fever 14 0 0
Anorexia 13 0 0
Pulmonary-Other 13 0 0
Insomnia 12 0 0
Pain- head 12 0 0
Pain- abdomen 10 1 0
Haemorrhage, nose 10 0 0
Oedema- limb 10 0 0
Pruritus 10 0 0
Gastrointestinal-Other 9 0 0
Diarrhoea 8 3 0
Dysphagia 8 1 0
Nausea 8 0 0
Pain- others 8 0 0
Platelets 7 4 0
Dyspnoea 7 1 0
Constipation 7 0 0
Distension 7 0 0
Dry mouth 7 0 0
Haemorrhage, other 6 0 0
Rigors/chills 6 0 0
Vomiting 6 0 0
Hyperglycaemia 5 1 0
Dizziness 5 0 0
Dry skin 5 0 0
Musculoskeletal-Other 5 0 0
Pain- muscle 5 0 0
Taste alteration 5 0 0
Hypokalaemia 4 1 1
Hemorrhoids 4 1 0
Hyponatraemia 0 4 0
Ascites 4 0 0
Infection- others with normal neutrophil counts 4 0 0
Alanine transaminase 3 2 0
Hyperbilirubinaemia 1 2 1
Infection- upper airway with normal neutrophil counts 1 3 0