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Table 2 miRNAs with significantly different levels in disease groups compared to normal in the discovery cohort

From: Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progression

MiRNAs

Normal vs Polyp

Normal vs Adenoma

Normal vs Early Cancer

Normal vs Late Cancer

Log2FC

P Value

Log2FC

P Value

Log2FC

P Value

Log2FC

P Value

hsa-let-7b

−0.823

0.007

−0.618

0.038

−0.712

0.083

−0.298

0.328

hsa-let-7c

3.407

0.442

4.27

0.136

4.794

0.105

0.812

0.753

hsa-let-7g

−0.749

0.195

−0.231

0.153

−1.177

0.010

−3.933

0.234

hsa-miR-135a

13.518

0.050

0.614

0.968

−5.76

0.171

3.738

0.655

hsa-miR-140-5p

0.672

0.038

0.122

0.834

0.558

0.083

−2.645

0.021

hsa-miR-146b-3p

11.496

0.281

−1.962

0.511

−1.377

0.904

10.34

0.043

hsa-miR-150

−0.523

0.161

−0.706

0.032

−1.491

0.015

−2.771

0.000

hsa-miR-15b

−0.538

0.130

−0.362

0.238

−2.019

0.001

−0.746

0.105

hsa-miR-182

7.054

0.178

−2.384

0.864

−3.173

0.685

−11.924

0.032

hsa-miR-183

−0.192

0.599

−1.533

0.667

−3.09

0.792

−15.707

0.010

hsa-miR-190

−0.139

0.874

−9.03

0.043

−16.68

0.018

−7.941

0.075

hsa-miR-191

0.138

0.505

−0.049

0.383

−0.979

0.083

0.509

0.279

hsa-miR-192

3.363

0.721

2.913

0.061

3.349

0.505

−2.113

0.036

hsa-miR-193a-5p

4.76

0.105

2.668

0.417

3.744

0.798

−1.73

0.012

hsa-miR-194

2.184

0.105

2.992

0.452

3.008

0.234

−1.904

0.016

hsa-miR-199a-3p

1.037

1.000

−0.095

0.264

−0.217

0.234

−2.353

0.010

hsa-miR-19a

1.229

0.050

0.318

0.976

1.58

0.028

0.831

0.083

hsa-miR-19b

1.125

0.010

0.302

0.976

1.447

0.065

0.696

0.028

hsa-miR-204

12.069

0.005

6.087

0.096

6.565

0.751

3.338

0.790

hsa-miR-210

2.864

0.003

−3.207

0.927

1.987

0.028

−1.692

0.105

hsa-miR-21

−0.232

0.050

−0.239

0.238

0.561

0.130

−3.683

0.065

hsa-miR-219-1-3p

−2.985

0.382

−1.557

0.610

3.221

0.488

8.939

0.142

hsa-miR-23a

3.751

0.574

−1.265

0.667

0.948

0.400

3.146

0.012

hsa-miR-25

0.717

0.721

0.052

0.120

0.853

0.574

−0.621

0.038

hsa-miR-30b

0.04

0.721

−0.117

0.452

−0.964

0.028

−0.88

0.130

hsa-miR-30c

−0.017

0.878

−0.231

0.172

−0.845

0.038

−6.451

0.038

hsa-miR-323-3p

−0.461

0.328

0.328

0.452

0.243

0.574

−2.93

0.130

hsa-miR-337-5p

6.448

0.359

4.019

0.391

3.964

0.547

12.303

0.007

hsa-miR-34a

18.817

0.003

12.09

0.119

15.428

0.018

11.626

0.055

hsa-miR-365

0.257

0.878

−1.16

0.061

−0.884

0.279

−5.763

0.010

hsa-miR-370

9.181

0.040

4.218

0.283

−2.578

0.790

6.114

0.065

hsa-miR-377

0

NA

4.206

0.221

3.063

0.382

14.295

0.013

hsa-miR-451

0.216

1.000

−0.341

0.120

−0.111

0.721

−1.955

0.007

hsa-miR-486-3p

−0.225

0.382

0.062

0.569

0.176

0.574

−5.158

0.010

hsa-miR-486-5p

−0.813

0.065

−0.241

0.787

−0.562

0.798

−2.187

0.003

hsa-miR-500

−5.223

0.018

−6.169

0.084

−11.283

0.007

−9.256

0.011

hsa-miR-503

−3.035

0.382

−1.631

0.610

−3.035

0.382

7.943

0.225

hsa-miR-532-3p

2.845

0.195

3.061

0.452

1.402

0.015

2.436

0.050

hsa-miR-532-5p

4.749

0.105

3.772

0.787

4.688

0.130

0.31

0.834

hsa-miR-542-3p

3.213

0.382

0

NA

0

NA

7.988

0.076

hsa-miR-548d-3p

−3.186

0.382

−0.077

0.958

2.882

0.700

12.243

0.117

hsa-miR-548d-5p

9.445

0.076

1.349

0.536

2.736

0.382

14.573

0.013

hsa-miR-654-3p

10.564

0.012

4.161

0.153

3.815

0.250

11.441

0.007

hsa-miR-660

0.544

0.234

0.228

0.106

0.447

0.721

−4.865

0.007

RNU48

−3.549

0.365

1.637

0.878

−12.871

0.064

−7.855

0.075

hsa-let-7a-3p

10.399

0.148

8.684

0.217

−6.667

0.171

10.717

0.118

hsa-miR-135-3p

−0.835

0.195

−0.512

0.417

−1.688

0.002

−2.27

0.001

hsa-miR-136-3p

5.14

0.028

−0.617

0.357

−0.031

1.000

2.942

0.016

hsa-miR-138-1-3p

−0.353

0.065

−0.038

0.697

−0.033

0.721

−1.37

0.038

hsa-miR-144-5p

−1.373

0.065

−1.208

0.011

−3.164

0.001

−2.299

0.028

hsa-miR-151-3p

0.398

0.574

0.343

0.697

0.623

0.574

2.57

0.007

hsa-miR-16-1-3p

2.883

0.873

−7.605

0.117

7.397

0.290

4.03

0.424

hsa-miR-221-5p

−6.94

0.171

1.828

0.732

−6.94

0.171

10.556

0.183

hsa-miR-222-5p

3.311

0.566

−3.168

0.479

−2.906

0.590

12.137

0.104

hsa-miR-25-5p

18.99

0.018

5.097

0.334

17.026

0.024

12.007

0.117

hsa-miR-30a-3p

0.171

0.382

−0.048

0.881

0.736

0.003

−3.516

0.279

hsa-miR-30e-3p

−0.136

0.959

−0.8

0.038

−1.034

0.038

−1.083

0.574

hsa-miR-30e

0.798

0.003

−0.048

0.881

1.107

0.010

0.466

0.065

hsa-miR-497

5.305

0.004

−0.143

0.302

5.1

0.011

4.304

0.001

hsa-miR-509-3p

−0.329

0.083

−0.06

0.653

0.825

0.234

−5.263

0.007

hsa-miR-559

−11.278

0.009

1.504

0.991

1.144

0.804

−7.323

0.007

hsa-miR-605

−3.301

0.164

4.458

0.233

−0.111

0.974

12.867

0.006

hsa-miR-609

−1.583

0.349

−0.832

0.613

−0.1

1.000

1.618

0.576

hsa-miR-610

−0.557

0.038

−0.463

0.291

0.493

0.382

−1.327

0.021

hsa-miR-632

−0.766

0.105

−0.495

0.350

0.176

0.721

−2.335

0.010

hsa-miR-645

−1.016

0.019

−0.628

0.135

−0.426

0.224

−5.643

0.001

hsa-miR-668

14.982

0.004

7.463

0.072

−2.096

0.549

11.805

0.017

hsa-miR-7

4.86

0.181

1.229

0.437

5.291

0.048

0.28

0.611

hsa-miR-768-3p

6.126

0.085

−7.483

0.206

−9.603

0.059

−9.625

0.059

hsa-miR-801

1.108

0.270

−0.261

0.787

−3.102

0.000

−6.163

0.008

hsa-miR-923

−1.635

0.000

−1.184

0.001

−2.833

0.000

−6.284

0.007

RNU24

11.491

0.000

9.167

0.000

1.901

0.291

3.178

0.089

RNU48

−3.073

0.074

0.595

0.649

−10.127

0.001

−9.95

0.000

  1. miRNAs highlighted in bold were chosen for validation in the validation cohort of 97 plasma samples.