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Table 2 miRNAs with significantly different levels in disease groups compared to normal in the discovery cohort

From: Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progression

MiRNAs Normal vs Polyp Normal vs Adenoma Normal vs Early Cancer Normal vs Late Cancer
Log2FC P Value Log2FC P Value Log2FC P Value Log2FC P Value
hsa-let-7b −0.823 0.007 −0.618 0.038 −0.712 0.083 −0.298 0.328
hsa-let-7c 3.407 0.442 4.27 0.136 4.794 0.105 0.812 0.753
hsa-let-7g −0.749 0.195 −0.231 0.153 −1.177 0.010 −3.933 0.234
hsa-miR-135a 13.518 0.050 0.614 0.968 −5.76 0.171 3.738 0.655
hsa-miR-140-5p 0.672 0.038 0.122 0.834 0.558 0.083 −2.645 0.021
hsa-miR-146b-3p 11.496 0.281 −1.962 0.511 −1.377 0.904 10.34 0.043
hsa-miR-150 −0.523 0.161 −0.706 0.032 −1.491 0.015 −2.771 0.000
hsa-miR-15b −0.538 0.130 −0.362 0.238 −2.019 0.001 −0.746 0.105
hsa-miR-182 7.054 0.178 −2.384 0.864 −3.173 0.685 −11.924 0.032
hsa-miR-183 −0.192 0.599 −1.533 0.667 −3.09 0.792 −15.707 0.010
hsa-miR-190 −0.139 0.874 −9.03 0.043 −16.68 0.018 −7.941 0.075
hsa-miR-191 0.138 0.505 −0.049 0.383 −0.979 0.083 0.509 0.279
hsa-miR-192 3.363 0.721 2.913 0.061 3.349 0.505 −2.113 0.036
hsa-miR-193a-5p 4.76 0.105 2.668 0.417 3.744 0.798 −1.73 0.012
hsa-miR-194 2.184 0.105 2.992 0.452 3.008 0.234 −1.904 0.016
hsa-miR-199a-3p 1.037 1.000 −0.095 0.264 −0.217 0.234 −2.353 0.010
hsa-miR-19a 1.229 0.050 0.318 0.976 1.58 0.028 0.831 0.083
hsa-miR-19b 1.125 0.010 0.302 0.976 1.447 0.065 0.696 0.028
hsa-miR-204 12.069 0.005 6.087 0.096 6.565 0.751 3.338 0.790
hsa-miR-210 2.864 0.003 −3.207 0.927 1.987 0.028 −1.692 0.105
hsa-miR-21 −0.232 0.050 −0.239 0.238 0.561 0.130 −3.683 0.065
hsa-miR-219-1-3p −2.985 0.382 −1.557 0.610 3.221 0.488 8.939 0.142
hsa-miR-23a 3.751 0.574 −1.265 0.667 0.948 0.400 3.146 0.012
hsa-miR-25 0.717 0.721 0.052 0.120 0.853 0.574 −0.621 0.038
hsa-miR-30b 0.04 0.721 −0.117 0.452 −0.964 0.028 −0.88 0.130
hsa-miR-30c −0.017 0.878 −0.231 0.172 −0.845 0.038 −6.451 0.038
hsa-miR-323-3p −0.461 0.328 0.328 0.452 0.243 0.574 −2.93 0.130
hsa-miR-337-5p 6.448 0.359 4.019 0.391 3.964 0.547 12.303 0.007
hsa-miR-34a 18.817 0.003 12.09 0.119 15.428 0.018 11.626 0.055
hsa-miR-365 0.257 0.878 −1.16 0.061 −0.884 0.279 −5.763 0.010
hsa-miR-370 9.181 0.040 4.218 0.283 −2.578 0.790 6.114 0.065
hsa-miR-377 0 NA 4.206 0.221 3.063 0.382 14.295 0.013
hsa-miR-451 0.216 1.000 −0.341 0.120 −0.111 0.721 −1.955 0.007
hsa-miR-486-3p −0.225 0.382 0.062 0.569 0.176 0.574 −5.158 0.010
hsa-miR-486-5p −0.813 0.065 −0.241 0.787 −0.562 0.798 −2.187 0.003
hsa-miR-500 −5.223 0.018 −6.169 0.084 −11.283 0.007 −9.256 0.011
hsa-miR-503 −3.035 0.382 −1.631 0.610 −3.035 0.382 7.943 0.225
hsa-miR-532-3p 2.845 0.195 3.061 0.452 1.402 0.015 2.436 0.050
hsa-miR-532-5p 4.749 0.105 3.772 0.787 4.688 0.130 0.31 0.834
hsa-miR-542-3p 3.213 0.382 0 NA 0 NA 7.988 0.076
hsa-miR-548d-3p −3.186 0.382 −0.077 0.958 2.882 0.700 12.243 0.117
hsa-miR-548d-5p 9.445 0.076 1.349 0.536 2.736 0.382 14.573 0.013
hsa-miR-654-3p 10.564 0.012 4.161 0.153 3.815 0.250 11.441 0.007
hsa-miR-660 0.544 0.234 0.228 0.106 0.447 0.721 −4.865 0.007
RNU48 −3.549 0.365 1.637 0.878 −12.871 0.064 −7.855 0.075
hsa-let-7a-3p 10.399 0.148 8.684 0.217 −6.667 0.171 10.717 0.118
hsa-miR-135-3p −0.835 0.195 −0.512 0.417 −1.688 0.002 −2.27 0.001
hsa-miR-136-3p 5.14 0.028 −0.617 0.357 −0.031 1.000 2.942 0.016
hsa-miR-138-1-3p −0.353 0.065 −0.038 0.697 −0.033 0.721 −1.37 0.038
hsa-miR-144-5p −1.373 0.065 −1.208 0.011 −3.164 0.001 −2.299 0.028
hsa-miR-151-3p 0.398 0.574 0.343 0.697 0.623 0.574 2.57 0.007
hsa-miR-16-1-3p 2.883 0.873 −7.605 0.117 7.397 0.290 4.03 0.424
hsa-miR-221-5p −6.94 0.171 1.828 0.732 −6.94 0.171 10.556 0.183
hsa-miR-222-5p 3.311 0.566 −3.168 0.479 −2.906 0.590 12.137 0.104
hsa-miR-25-5p 18.99 0.018 5.097 0.334 17.026 0.024 12.007 0.117
hsa-miR-30a-3p 0.171 0.382 −0.048 0.881 0.736 0.003 −3.516 0.279
hsa-miR-30e-3p −0.136 0.959 −0.8 0.038 −1.034 0.038 −1.083 0.574
hsa-miR-30e 0.798 0.003 −0.048 0.881 1.107 0.010 0.466 0.065
hsa-miR-497 5.305 0.004 −0.143 0.302 5.1 0.011 4.304 0.001
hsa-miR-509-3p −0.329 0.083 −0.06 0.653 0.825 0.234 −5.263 0.007
hsa-miR-559 −11.278 0.009 1.504 0.991 1.144 0.804 −7.323 0.007
hsa-miR-605 −3.301 0.164 4.458 0.233 −0.111 0.974 12.867 0.006
hsa-miR-609 −1.583 0.349 −0.832 0.613 −0.1 1.000 1.618 0.576
hsa-miR-610 −0.557 0.038 −0.463 0.291 0.493 0.382 −1.327 0.021
hsa-miR-632 −0.766 0.105 −0.495 0.350 0.176 0.721 −2.335 0.010
hsa-miR-645 −1.016 0.019 −0.628 0.135 −0.426 0.224 −5.643 0.001
hsa-miR-668 14.982 0.004 7.463 0.072 −2.096 0.549 11.805 0.017
hsa-miR-7 4.86 0.181 1.229 0.437 5.291 0.048 0.28 0.611
hsa-miR-768-3p 6.126 0.085 −7.483 0.206 −9.603 0.059 −9.625 0.059
hsa-miR-801 1.108 0.270 −0.261 0.787 −3.102 0.000 −6.163 0.008
hsa-miR-923 −1.635 0.000 −1.184 0.001 −2.833 0.000 −6.284 0.007
RNU24 11.491 0.000 9.167 0.000 1.901 0.291 3.178 0.089
RNU48 −3.073 0.074 0.595 0.649 −10.127 0.001 −9.95 0.000
  1. miRNAs highlighted in bold were chosen for validation in the validation cohort of 97 plasma samples.