Table 3 Univariate analysis of prognostic factors in patients with brain metastasis of GTN
Clinical Factors | Survival rate (%) | Pvalue |
|---|---|---|
Age | Â | Â |
<40(n = 92) | 73.9 |  |
≥40(n = 9) | 33.3 | 0.020 |
Antecedent pregnancy | Â | Â |
Abortion(n = 24) | 50 |  |
Mole(n = 36) | 75 |  |
Term(n = 41) | 78 | 0.063 |
Interval time(mos.) from antecedent pregnancy | Â | Â |
<13(n = 38) | 84.2 |  |
≥13(n = 63) | 61.9 | 0.018 |
No. of metastasis | Â | Â |
≤4(n = 86) | 70.9 |  |
>4(n = 15) | 66.7 | 0.461 |
Pretreatment serum β-hCG level |  |  |
<100,000(n = 74) | 68.9 |  |
≥100,000(n = 27) | 74.1 | 0.576 |
No. of distant metastatic sitesa | Â | Â |
1(n = 71) | 78.9 |  |
≥2(n = 30) | 50 | 0.030 |
No. of multi-agent chemotherapy failure history | Â | Â |
No(n = 57) | 84.2 |  |
Yes(n = 44) | 52.3 | <0.001 |
Liver metastasis | Â | Â |
No(n = 86) | 74.4 |  |
Yes(n = 15) | 46.7 | 0.013 |
Kidney metastasis | Â | Â |
No(n = 90) | 73.3 |  |
Yes(n = 11) | 45.5 | 0.042 |
Pelvic surgeryb | Â | Â |
No(n = 75) | 74.7 |  |
Yes(n = 26) | 57.7 | 0.082 |
Lung surgeryc | Â | Â |
No(n = 68) | 67.6 |  |
Yes(n = 33) | 75.8 | 0.359 |
Craniotomy | Â | Â |
No(n = 77) | 66.2 |  |
Yes(n = 24) | 83.3 | 0.029 |
FIGO score | Â | Â |
≤12(n = 38) | 84.2 |  |
>12(n = 63) | 61.9 | 0.018 |