Table 2 Main results of meta-analysis for EGF +61A/G polymorphism and HCC risk

Overall

16

2475/5381

1.48 (1.20-1.84)*

69.3**

1.53 (1.22-1.92)*

53.5**

1.96 (1.43-2.68)*

65.2**

1.22 (1.04-1.42)*

19.7

1.38 (1.17-1.63)*

75.4**

Racial descent

 Asian

9

2018/3655

1.19 (1.06-1.34)*

24.9

1.20 (1.01-1.43)*

16.3

1.40 (1.14-1.71)*

1.3

1.10 (0.92-1.33)

23.5

1.15 (1.05-1.26)*

4.6

 European

2

62/438

2.10 (1.07-4.13)*

12.6

1.62 (0.84-3.13)

0.0

2.51 (1.11-5.71)*

0.0

1.30 (0.64-2.63)

0.0

1.59 (1.05-2.41)*

0.0

 African

2

153/165

6.33 (3.39-11.83)*

46.8

3.69 (2.23-6.10)*

0.0

9.34 (4.61-18.91)*

19.4

2.11 (1.21-3.67)*

0.0

3.60 (2.55-5.08)*

57.6

 Mixed

3

242/1123

1.55 (0.79-3.06)

77.3**

1.52 (1.08-2.16)*

46.9

1.94 (0.87-4.33)

73.1**

1.37 (0.94-2.00)

11.0

1.45 (0.93-2.26)

77.1**

Study quality

 High quality

9

1688/4339

1.22 (1.08-1.38)*

21.0

1.26 (1.04-1.52)*

0.0

1.36 (1.11-1.67)*

0.0

1.16 (0.94-1.42)

0.0

1.18 (1.08-1.29)*

0.0

  Asian

6

1487/3003

1.22 (1.07-1.38)*

0.0

1.23 (0.99-1.54)

8.5

1.34 (1.06-1.69)*

0.0

1.13 (0.89-1.43)

23.2

1.17 (1.06-1.29)*

0.0

  Others

3

201/1336

1.29 (0.65-2.58)

69.0**

1.32 (0.92-1.91)

0.0

1.45 (0.94-2.23)

37.6

1.25 (0.84-1.85)

0.0

1.22 (0.98-1.52)

50.0

 Low quality

7

787/1042

2.28 (1.23-4.23)*

82.7**

1.90 (1.17-3.09)*

74.3**

3.06 (1.62-5.76)*

72.9**

1.45 (1.02-2.07)*

44.1**

1.74 (1.14-2.65)*

87.1**

  Asian

3

531/652

1.31 (0.72-2.38)

69.6**

1.14 (0.86-1.51)

49.3

1.59 (1.05-2.43)*

32.8

1.07 (0.80-1.44)

48.8

1.14 (0.85-1.53)

60.5**

  Others

4

256/390

3.57 (1.94-6.60)*

53.4**

2.89 (1.98-4.20)*

22.6

5.67 (3.52-9.14)*

41.6

1.88 (1.25-2.82)*

0.0

2.47 (1.61-3.80)*

65.8**

Source of controls

 Population-based

5

940/1451

1.04 (0.88-1.24)

0.0

1.28 (0.99-1.67)

0.0

1.26 (0.94-1.67)

0.0

1.29 (0.98-1.71)

0.0

1.09 (0.96-1.24)

0.0

  Asian

3

805/1017

1.07 (0.89-1.29)

0.0

1.29 (0.94-1.77)

9.1

1.32 (0.95-1.84)

0.0

1.26 (0.90-1.76)

40.1

1.10 (0.95-1.27)

0.0

  Others

2

135/434

0.87 (0.54-1.40)

0.0

1.27 (0.79-2.02)

0.0

1.07 (0.60-1.90)

0.0

1.37 (0.83-2.25)

0.0

1.04 (0.78-1.39)

0.0

 Hospital-based

15

2358/3930

1.59 (1.27-1.99)*

67.3**

1.57 (1.21-2.04)*

58.5**

2.10 (1.49-2.96)*

66.6**

1.18 (1.00-1.39)

27.6

1.44 (1.21-1.72)*

75.8**

  Asian

9

2018/2638

1.23 (1.09-1.39)*

20.2

1.16 (0.97-1.40)

26.7

1.38 (1.11-1.71)*

22.6

1.06 (0.88-1.28)

24.6

1.16 (1.06-1.27)*

17.6

  Others

6

340/1292

2.79 (1.72-4.53)*

54.0**

2.31 (1.70-3.14)*

37.9

3.77 (2.07-6.88)*

55.5**

1.61 (1.16-2.25)*

0.0

2.08 (1.44-2.98)*

69.0**

Type of controls

 Healthy controls

8

1153/1708

1.10 (0.94-1.29)

34.3

1.40 (1.11-1.76)*

7.8

1.44 (1.11-1.86)*

31.7

1.35 (1.05-1.72)*

0.0

1.18 (1.00-1.41)

43.4**

  Asian

5

998/1254

1.11 (0.94-1.32)

36.8

1.36 (1.04-1.79)*

0.0

1.47 (1.09-1.97)*

8.5

1.28 (0.96-1.71)

0.0

1.14 (1.00-1.30)*

4.2

  Others

3

155/454

1.01 (0.65-1.57)

51.2

1.95 (0.81-4.73)

58.4**

2.08 (0.59-7.31)

65.1**

1.54 (0.96-2.47)

16.6

1.59 (0.77-3.29)

75.5**

 Patients with chronic liver diseases

12

1395/2696

1.74 (1.29-2.36)*

70.0**

1.87 (1.30-2.67)*

58.7**

2.58 (1.60-4.16)*

69.9**

1.36 (1.09-1.70)*

36.0

1.56 (1.23-1.99)*

76.9**

  Asian

5

1055/1424

1.19 (1.01-1.40)*

11.0

1.64 (0.95-2.84)

61.7**

1.77 (1.02-3.06)*

59.1**

1.53 (0.86-2.72)

62.6**

1.17 (1.03-1.32)*

23.3

  Others

7

340/1272

2.73 (1.74-4.28)*

45.2**

2.22 (1.64-3.01)*

34.2

3.53 (2.01-6.20)*

47.5**

1.55 (1.12-2.16)*

0.0

1.98 (1.41-2.79)*

64.4**

Number of cases

 ≥100

10

2195/3868

1.27 (1.01-1.60)*

72.6**

1.44 (1.07-1.94)*

66.1**

1.66 (1.13-2.43)*

71.8**

1.24 (0.98-1.58)

39.7**

1.26 (1.03-1.53)*

80.7**

  Asian

8

1945/3538

1.17 (1.04-1.32)*

0.0

1.16 (0.97-1.40)

16.6

1.34 (1.08-1.65)*

0.0

1.09 (0.90-1.32)

31.3

1.13 (1.04-1.24)*

0.0

  Others

2

250/330

2.50 (0.26-23.99)

95.8**

2.15 (0.63-7.34)

90.5**

3.27 (0.28-37.81)

95.5**

1.62 (1.08-2.44)*

36.5

2.00 (0.48-8.32)

96.9**

 <100

6

280/1513

2.28 (1.68-3.10)*

0.0

1.79 (1.31-2.45)*

0.0

2.82 (1.93-4.13)*

0.0

1.40 (1.00-1.96)

0.0

1.74 (1.43-2.12)*

0.0

  Asian

1

73/117

2.62 (1.20-5.74)*

-

1.63 (0.89-3.00)

-

3.00 (1.27-7.10)*

-

1.29 (0.67-2.49)

-

1.70 (1.11-2.59)*

-

  Others

5

207/1396

2.22 (1.59-3.10)*

0.0

1.85 (1.28-2.66)*

0.0

2.78 (1.82-4.25)*

0.0

1.44 (0.97-2.14)

0.0

1.75 (1.41-2.18)*

0.0